Description
Skin chronic wounds are still a major burden not only for patients and care givers but also for the healthcare system. This pathological condition is usually colonized by several types of microorganisms, namely bacteria and fungi, responsible by biofilm formation via microbial aggregation. The presence of biofilm has a negative impact on the wound-healing process and compromises the life quality of many patients. Currently, the gold standard treatment is based on high dosages of antibiotics, both orally or in situ administrated. However, this therapeutic approach is correlated with undesired side effects and increases antibiotic-resistant bacterial species. Therefore, the search for new antimicrobials as antibiofilm agents is an urgent issue for alternative treatments of skin chronic wounds. Considering that natural components are favorite candidates due to the lack of secondary effects and possible long-term usage in the skin, this work will explore the potential of plant extracts, as sources of bioactive compounds, to act as antibiofilm agents. This investigation can provide important insights into the antibiofilm potential of plant extract and may open door for the incorporation of natural compounds in formulations for the treatment of skin chronic wounds.| Period | 1 Sept 2023 → 15 Feb 2024 |
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| Held at | Universidade Católica Portuguesa |
| Degree of Recognition | Master |