Projects per year
Personal profile
Biography
Over the course of my career, my research interests have covered a broad range of subject s within the field of molecular biology, always focusing on the context of disease etiology and treatment. I began my scientific career on the study of molecular markers of hematological malignancies, and proceeded to a research project that envisioned the identification of novel molecular markers for breast carcinoma, with predictive and prognostic value. This latter project sharpened my interest for the intricacies of gene expression and my PhD work focused on the study of the mRNA surveillance mechanism, the nonsense mediated mRNA decay (NMD) pathway that detects and degrades transcript s harboring premature termination codons, which can be linked to several human disorders. My expertise in regulation of gene expression, gathered during my PhD, motivated me to direct my post -doctoral training to the field of post -transcriptional and translational control, focusing mainly on macromolecular complexes involved in mRNA metabolism and protein synthesis. Upon finishing my post-doc in 2010, I decided to expand my research on gene expression to the oncobiology field and I joined the Molecular Endocrinology group at the Portuguese Cancer Institute as a research associate. This gave me the opportunity to work in a highly interdisciplinary environment which was essential to improve and consolidate my knowledge in the field of thyroid cancer and other malignancies as well. At the beginning of 2016 I had the opportunity to establish myself as an independent group leader, integrated in the Ecogenetics and Human Health unit of the Instituto de Saúde Ambiental (ISAMB), a research and development (R&D) center at FM-UL. I am now committed to establish my independent research lines focusing on topics that can lead to novel translational results, covering both the identification of new prognostic biomarkers as well as new molecular mechanisms that could be explored to develop innovative therapeutic strategies for thyroid cancer and other endocrine malignancies.
Education/Academic qualification
PhD, Mammalian Nonsense-mediated mRNA Decay: New Determinants That Make Transcripts Bearing a Small Open Reading Resistant to Rapid Decay, University of Lisbon
Award Date: 1 Jan 2008
Bachelor, RT-PCR - Based Detection of Molecular Markers for Acute Leukaemia - Diagnosis and Minimal Residual Disease Evaluation, University of Lisbon
Award Date: 1 Jan 1998
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
Projects
- 1 Active
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The role of tumour microenvironment in the biological behaviour and outcomes of pituitary adenomas: new immune-related biomarkers and therapeutical targets
Silva, A. L. (PI), Marques, P. (CoPI), Faria, C. (Researcher) & Korbonits, M. (Researcher)
1/05/26 → 30/04/28
Project: Research
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Genomic ancestry and diversity in individuals with type 1 diabetes from Brazil and Portugal: a descriptive analysis
Ferreira, L. L., Vale, S. D., Duarte, M. A., Silva, A. L., Porto, L. C., Turchetto-Zolet, A. C., Silva, D. A. & Gomes, M. B., Dec 2026, In: Diabetology and Metabolic Syndrome. 18, 1, 11 p., 141.Research output: Contribution to journal › Article › peer-review
Open Access -
The emerging role of chemokines and chemokine receptors in the biological and clinical behaviour of pituitary neuroendocrine tumours: an exploratory transcriptomic study
Silva, A. L., Barry, S., Hipólito, A., Severino, M. D. G., Joaquim, R., Hall, C., Oliveira, T., López-Presa, D., Borrecho, G., Tortosa, F., Nobre, E., Faria, C. C., Korbonits, M. & Marques, P., Apr 2026, In: Journal of Neuroendocrinology. 38, 4, 16 p., e70184.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Downloads -
A novel patient-derived cutaneous melanoma cell line reveals key features of metastatic melanoma
Tomás, A., Roque, L., Francisco, I., Silva, A. L., Nunes, H., Gouveia, E., Carvalho, E., Farricha, V., Moura, C., Rosa, J. C., Garrido, P. M., Albuquerque, C., Pereira, P. M., Cabral, M. G. & Pojo, M., 18 Jul 2025, In: Frontiers in Oncology. 15, 14 p., 1531013.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus) -
CCL2 expression predicts clinical outcomes and regulates E-cadherin and angiogenesis in pituitary tumours
Silva, A. L., Barry, S., Lopes-Pinto, M., Joaquim, R., Miranda, C., Reis, F., Miranda, M., Matos, P., Suleyman, O., Oliveira, T., López-Presa, D., Borrecho, G., Tortosa, F., Faria, C. C., Korbonits, M. & Marques, P., 24 Mar 2025, In: Endocrine-Related Cancer. 32, 5, e240293.Research output: Contribution to journal › Article › peer-review
5 Citations (Scopus) -
Thyroid surgery outcomes in a 4-year series with intraoperative neuromonitoring: a retrospective cohort study
Allen, M., Palma, C., Branco, C., Resende, C., Vieira, N., Silva, A. L. & Rosário, F. S. D., 31 Jul 2025, In: Gland Surgery. 14, 7, p. 1230-1241 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile22 Downloads
Datasets
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A novel patient-derived cutaneous melanoma cell line reveals key features of metastatic melanoma (Project: PRJEB92110)
Tomás Mateus, A. D. A. (Contributor), Roque, L. (Contributor), Francisco, I. (Contributor), Silva, A. L. (Contributor), Nunes, H. (Contributor), Gouveia, E. (Contributor), Carvalho, E. (Contributor), Farricha, V. (Contributor), Moura, C. (Contributor), Rosa, J. C. (Contributor), Garrido, P. M. (Contributor), Albuquerque, C. (Contributor), Pereira, P. M. (Contributor) & Pojo, M. (Creator), European Nucleotide Archive, 9 Jul 2025
https://www.ebi.ac.uk/ena/browser/view/PRJEB92110
Research data