Projects per year
Personal profile
Biography
Understanding what drives leukemia growth and thriving is crucial to fight these diseases. Despite the recent advances in understanding the pathophysiology of several myeloid malignancies, treatment options remain highly limited and are not curative for most of these patients.
Our main goal is to uncover disease biology and use such discoveries to design novel, therapeutic regiments that maximize treatment efficacy while minimize the severe side effects associated with the standard chemotherapy.
In line with this, two independent research avenues are in place in the Lab to tackle these aggressive malignancies:
- Cross-talk between Leukemic cells and bone marrow microenvironment
- Linking the circadian molecular clock to myeloid leukemogenesis
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Doutoramento em Ciências Biomédicas - Especialidade Ciências Morfológicas, University of Lisbon
1 Jan 2006 → 20 Dec 2011
Award Date: 20 Dec 2011
Bachelor, Licenciatura em Biologia Microbiana e Genética (pré-Bolonha), University of Lisbon
20 Sept 2000 → 6 Oct 2005
Award Date: 6 Oct 2005
Keywords
- RM Therapeutics. Pharmacology
- Novel therapeutic targets
- LB2300 Higher Education
- Q Science (General)
- RC0254 Neoplasms. Tumors. Oncology (including Cancer)
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Collaborations and top research areas from the last five years
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Projects
- 2 Finished
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SPIT-it-AML: Saliva from Patients with cancer: searching for novel prognostic markers in Acute Myeloid Leukemia
Cardoso, B. A. (PI), Silva, R. (Researcher), Rosa, N. (Researcher), Mendes, K. (Researcher), Almeida, A. (Researcher) & Gomes, A. P. (Researcher)
1/07/22 → 31/12/23
Project: Research
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The reciprocal regulation between the circadian molecular clock and IL7/ IL7R-mediated signalling in T-cell Acute Lymphoblastic Leukemia.
Cardoso, B. A. (PI), Rijo-ferreira, F. F. (CoPI), Barata, J. P. T. J. P. T. (CoPI), Dias, C. L. G. C. L. G. (CoPI) & Cachucho, A. P. C. A. P. C. (CoPI)
Fundação para a Ciência e a Tecnologia
1/01/22 → 30/06/23
Project: Research
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The bone marrow niche - the tumor microenvironment that ensures leukemia progression
Cardoso, B. A., 5 Mar 2020, Advances in experimental medicine and biology: Tumor microenvironment. Springer, Vol. 1219. p. 259-293 35 p. (Advances in Experimental Medicine and Biology; vol. 1219).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
4 Citations (Scopus) -
The bone marrow-mediated protection of myeloproliferative neoplastic cells to vorinostat and ruxolitinib relies on the activation of JNK and PI3K Signalling Pathways
Cardoso, B. A., Belo, H., Barata, J. T. & Almeida, A. M., 1 Dec 2015, In: PLoS one. 10, 12, e0143897.Research output: Contribution to journal › Article › peer-review
Open Access12 Citations (Scopus) -
Vorinostat synergizes with antioxidant therapy to target myeloproliferative neoplasms
Cardoso, B. A., Ramos, T. L., Belo, H., Vilas-Boas, F., Real, C. & Almeida, A. M., Apr 2019, In: Experimental Hematology. 72, p. 60-71.e11Research output: Contribution to journal › Article › peer-review
6 Citations (Scopus) -
Editorial: two decades of targeted therapies in hematology: new targets and novel combinations
Cardoso, B. A. & Neparidze, N., 24 Jan 2025, In: Frontiers in Hematology. 4, 3 p., 1548984.Research output: Contribution to journal › Editorial
Open AccessFile -
CASZ1 upregulates PI3K-AKT-mTOR signaling and promotes T-cell acute lymphoblastic leukemia
Cardoso, B. A., Duque, M., Gírio, A., Fragoso, R., Oliveira, M. L., Allen, J. R., Martins, L. R., Correia, N. C., Silveira, A. B., Veloso, A., Kimura, S., Demoen, L., Matthijssens, F., Jeha, S., Cheng, C., Pui, C. H., Grosso, A. R., Neto, J. L., de Almeida, S. F. & Van Vlieberghe, P. & 5 others, , Jun 2024, In: Haematologica. 109, 6, p. 1713-1714 2 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)11 Downloads