Personal profile
Biography
For the last 5 years, and after ~20 years of biomedical research, I have been working in science education. At the CBR I am focusing on science and health literacy. As a biomedical researcher, my longstanding interests are host-pathogen interactions, particularly cellular processes manipulated by pathogenic microorganisms such as viruses and parasites and at the interface between cell biology and immunology. My lab research experience (2000-2018) provided me with in depth knowledge of adaptive and innate immunity, viral immune evasion strategies, and various aspects of the cell biology of infection in the context of DNA (herpesviruses, namely human cytomegalovirus) and RNA viruses (flaviviruses, namely hepatitis C virus), as well as of the apicomplexan parasite Toxoplasma gondii. My PhD thesis work on viral immune evasion and ER-associated degradation (ERAD) was done under the supervision of Professor Hidde L. Ploegh at the Harvard Medical School and at the Massachusetts Institute of Technology´s Whitehead Institute. I had 2 post-doctoral experiences: one at the Rockefeller University, working on hepatitis C virus infectivity under the mentorship of Professor Charles M. Rice (2008-2013), and the second one at the Instituto Gulbenkian de Ciência, in which I worked on innate immunity against Toxoplasma gondii with Professor Jonathan C. Howard as my mentor (2014-2019). During this postdoc at the IGC I was awarded a Marie Curie fellowship - IF 708694: Cytoplasmic sensing of Toxoplasma gondii infection and host cell programmed necrosis (Acronym: "Toxoplasma sensing"). In 2019 I pivoted to the endlessly creative world of science education as a co-director of the Instituto Gulbenkian de Ciência outreach project "Lab in a Box - future with science", a science teacher-focused project aimed at fostering the implementation of experimental science classes in Oeiras elementary and junior high school classes. I joined the CBR in late 2022 to direct its "Science and Health Literacy in Oeiras" programme, or "Lit Up" for short, a CBR/Oeiras Valley partnership aimed at promoting scientific literacy as well as health Literacy for all in the municipality of Oeiras, with a focus on high school students and teachers.
Education/Academic qualification
Other, Post-graduate course in Health Literacy, Institute of Applied Psychology
20 Jan 2024 → 14 Dec 2024
Award Date: 26 Dec 2024
PhD, Viral manipulation of antigen presentation: the HCMV US2 imunoevasin and endoplasmic reticulum-associated degradation (ERAD), University of Lisbon
23 Jan 2002 → 17 May 2007
Award Date: 17 May 2007
Bachelor, Biology, University of Porto
30 Sept 1995 → 16 Oct 1999
Award Date: 16 Oct 1999
Keywords
- Q Science (General)
- QR180 Immunology
- QR355 Virology
- RB Pathology
- LB1501 Primary Education
- LB1603 Secondary Education. High schools
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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- 1 Similar Profiles
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Methods for the measurement of early events in toxoplasma gondii immunity in mouse cells
Alvarez, C., Campos, A. C., Howard, J. C., Loureiro, J., Müller, U. B. & Rodrigues, A. L., 23 Nov 2019, Toxoplasma gondii: methods and protocols. Tonkin, C. J. (ed.). 1 ed. New York: Humana Press Inc., Vol. 2071. p. 371-409 39 p. (Methods in Molecular Biology; vol. 2071).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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Different requirements for scavenger receptor class B type I in hepatitis C virus cell-free versus cell-to-cell transmission
Catanese, M. T., Loureiro, J., Jones, C. T., Dorner, M., von Hahn, T. & Rice, C. M., 2013, In: Journal of Virology. 87, 15, p. 8282-8293 12 p.Research output: Contribution to journal › Article › peer-review
69 Citations (Scopus) -
Mechanism-based probe for the analysis of cathepsin cysteine proteases in living cells.
Hang, H. C., Loureiro, J., Spooner, E., van der Velden, A. W. M., Kim, Y. M., Pollington, A. M., Maehr, R., Starnbach, M. N. & Ploegh, H. L., 20 Dec 2006, In: ACS Chemical Biology. 1, 11, p. 713-723 11 p.Research output: Contribution to journal › Article › peer-review
73 Citations (Scopus) -
Viral immune evasion strategies: the human cytomegalovirus US2 immunoevasin and protein degradation from the endoplasmic reticulum
Loureiro, J., 2007, 168 p.Research output: Types of Thesis › Doctoral Thesis
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Signal peptide peptidase is required for dislocation from the endoplasmic reticulum
Loureiro, J., Lilley, B. N., Spooner, E., Noriega, V., Tortorella, D. & Ploegh, H. L., 15 Jun 2006, In: Nature. 441, 7095, p. 894-897 4 p.Research output: Contribution to journal › Article › peer-review
124 Citations (Scopus)