New therapeutic targets for spinal cord regeneration

  • Moura, Gabriela R. (PI)
  • Vieira, Sandra Isabel Moreira Pinto S.I.M.P. (CoPI)
  • Da Costa Rebelo, Sandra Maria Tavares S.M.T. (CoPI)
  • De Aguiar Pereira Marques, Paula Alexandrina P.A. (CoPI)
  • Vieira, Sandra Isabel Moreira Pinto S.I.M.P. (CoPI)
  • Da Costa Rebelo, Sandra Maria Tavares S.M.T. (CoPI)
  • De Aguiar Pereira Marques, Paula Alexandrina P.A. (CoPI)
  • De Aguiar Pereira Marques, Paula Alexandrina P.A. (CoPI)
  • Silva, Raquel (CoPI)
  • Costa, Tatiana Lima De Vilhena Magalhães (CoPI)
  • Da Rocha Alves, Mariana Isabel Quaresma M.I.Q. (CoPI)
  • Amaro, António José Monteiro (CoPI)
  • Edmond Reis da Silva Augusto, Ana Andreia (CoPI)
  • Costa, Rui (CoPI)
  • Dos Santos Dias, Roberto Alexandre R.A. (CoPI)
  • Werner, M. Hans (CoPI)
  • Neves, Diogo André Teixeira (CoPI)
  • Correia, Patícia Maria Dias (CoPI)
  • Pereira, Sara Capas Peneda Vieira S.C.P.V. (CoPI)
  • Bosse, Frank Otto F.O. (CoPI)
  • Araya, Victor Carriel (CoPI)
  • Estrada, Veronica V. (CoPI)
  • Da Silva, Augusto Marques Ferreira A.M.F. (CoPI)

Project Details

Description

GoBack is a research project that aims at delivering novel molecular targets for repairing lesions to the spinal cord SCI, which cannot regenerate. SCI leads to loss of function and autonomy, poor life quality, and high economic burden. SCI affects 40-80/million persons per year mainly male adults and the elderly and correspond up to 2% of all cases admitted to a veterinary hospital. No effective treatment exists, and managing SCI is thus a priority.

Using cutting-edge technologies, as Next Generation Sequencing, and by in-individual comparison of the responses triggered by nerve lesions on central non-regenerative and peripheral regenerative rat neurons, GoBack will identify a small set of key regulatory genes able to drive a neuroregenerative program.

University of Aveiro host iBiMED; ESSUA; TEMA and Dusseldorf and Granada Universities expert on SCI and Regenerative Medicine are the GoBack partners. Clinicians of the region will be enrolled in the final project phase for knowledge transfer.

AcronymGoBack
StatusFinished
Effective start/end date22/06/1821/06/22

Funding

  • Fundação para a Ciência e a Tecnologia: €238,419.00

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

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