Using microbial genomics, mathematical modelling and deep learning to investigate the relationship between core gene redundancy and antibiotic resistance

Project Details

Description

This integrative approach will provide a new conceptual framework that may pose a challenge to the traditional megaplasmid/chromid divide, and unravel a potentially new class of large 2nd replicons with genetic signatures that may differ from those of chromids and megaplasmids. On top of that, this ground-breaking project will pinpoint the role of large 2nd replicons in acquiring genes involved in host adaptation, and how relevant functions such as antibiotic resistance and DNA repair/recombination are preserved over evolutionary timescales.
Short titleUsing microbial genomics, mathematical modelling and deep learning to investigate the relationship between core gene redundancy and antibiotic resistance
StatusNot started

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