A broad spectrum secreted chemokine binding protein encoded by a herpesvirus

Christopher M. Parry, J. Pedro Simas, Vincent P. Smith, C. Andrew Stewart, Anthony C. Minson, Stacey Efstathiou*, Antonio Alcami

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

191 Citations (Scopus)

Abstract

Chemokines are a family of small proteins that interact with seven-transmembrane domain receptors and modulate the migration of immune cells into sites of inflammation and infection. The murine gammaherpesvirus 68 M3 gene encodes a secreted 44-kD protein with no sequence similarity to known chemokine receptors. We show that M3 binds a broad range of chemokines, including CC, CXC, C, and CX3C chemokines, but does not bind human B cell-specific nor mouse neutrophil-specific CXC chemokines. This herpesvirus chemokine binding protein (hvCKBP) blocks the interaction of chemokines with high-affinity cellular receptors and inhibits chemokine-induced elevation of intracellular calcium levels. hvCKBP is the first soluble chemokine receptor identified in herpesviruses; it represents a novel protein structure with the ability to bind all subfamilies of chemokines in solution and has potential therapeutic applications.
Original languageEnglish
Pages (from-to)573-578
Number of pages6
JournalJournal of Experimental Medicine
Volume191
Issue number3
DOIs
Publication statusPublished - 7 Feb 2000
Externally publishedYes

Keywords

  • Anti-inflammatory protein
  • Chemokine
  • Cytokine receptor
  • Viral immune evasion
  • Virus

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