A methanolic extract of Ganoderma lucidum fruiting body inhibits the growth of a gastric cancer cell line and affects cellular autophagy and cell cycle

Marta Oliveira; Filipa S. Reis; Diana Sousa; Catarina Tavares; Raquel T. Lima; Isabel C.F.R. Ferreira; Tiago Dos Santos; M. Helena Vasconcelos

doi:10.1039/c4fo00258j

A methanolic extract of Ganoderma lucidum fruiting body inhibits the growth of a gastric cancer cell line and affects cellular autophagy and cell cycle

Marta Oliveira, Filipa S. Reis, Diana Sousa, Catarina Tavares, Raquel T. Lima, Isabel C.F.R. Ferreira^*, Tiago Dos Santos, M. Helena Vasconcelos

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Ganoderma lucidum is one of the most extensively studied mushrooms as a functional food and as a chemopreventive agent due to its recognized medicinal properties. Some G. lucidum extracts have shown promising antitumor potential. In this study, the bioactive properties of various extracts of G. lucidum, from both the fruiting body and the spores, were investigated. The most potent extract identified was the methanolic fruiting body extract, which inhibited the growth of a gastric cancer cell line (AGS) by interfering with cellular autophagy and cell cycle. This journal is

Original language	English
Pages (from-to)	1389-1394
Number of pages	6
Journal	Food and Function
Volume	5
Issue number	7
DOIs	https://doi.org/10.1039/c4fo00258j
Publication status	Published - Jul 2014
Externally published	Yes

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abstract = "Ganoderma lucidum is one of the most extensively studied mushrooms as a functional food and as a chemopreventive agent due to its recognized medicinal properties. Some G. lucidum extracts have shown promising antitumor potential. In this study, the bioactive properties of various extracts of G. lucidum, from both the fruiting body and the spores, were investigated. The most potent extract identified was the methanolic fruiting body extract, which inhibited the growth of a gastric cancer cell line (AGS) by interfering with cellular autophagy and cell cycle. This journal is",

author = "Marta Oliveira and Reis, {Filipa S.} and Diana Sousa and Catarina Tavares and Lima, {Raquel T.} and Ferreira, {Isabel C.F.R.} and {Dos Santos}, Tiago and Vasconcelos, {M. Helena}",

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AU - Oliveira, Marta

AU - Reis, Filipa S.

AU - Sousa, Diana

AU - Tavares, Catarina

AU - Lima, Raquel T.

AU - Ferreira, Isabel C.F.R.

AU - Dos Santos, Tiago

AU - Vasconcelos, M. Helena

PY - 2014/7

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A methanolic extract of Ganoderma lucidum fruiting body inhibits the growth of a gastric cancer cell line and affects cellular autophagy and cell cycle

Abstract

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