A Portuguese expert panel position paper on the management of heart failure with preserved ejection fraction - part I: pathophysiology, diagnosis and treatment

José Silva-Cardoso; Emília Moreira; Rachel Tavares de Melo; Pedro Moraes-Sarmento; Nuno Cardim; Mário Oliveira; Cristina Gavina; Brenda Moura; Inês Araújo; Paulo Santos; Marisa Peres; Cândida Fonseca; João Pedro Ferreira; Irene Marques; Aurora Andrade; Rui Baptista; Dulce Brito; Rui Cernadas; Jonathan dos Santos; Adelino Leite-Moreira; Lino Gonçalves; Jorge Ferreira; Carlos Aguiar; Manuela Fonseca; Ricardo Fontes-Carvalho; Fátima Franco; Carolina Lourenço; Elisabete Martins; Hélder Pereira; Mário Santos; Joana Pimenta

doi:10.1016/j.repc.2024.11.011

A Portuguese expert panel position paper on the management of heart failure with preserved ejection fraction - part I: pathophysiology, diagnosis and treatment

José Silva-Cardoso^*, Emília Moreira, Rachel Tavares de Melo, Pedro Moraes-Sarmento, Nuno Cardim, Mário Oliveira, Cristina Gavina, Brenda Moura, Inês Araújo, Paulo Santos, Marisa Peres, Cândida Fonseca, João Pedro Ferreira, Irene Marques, Aurora Andrade, Rui Baptista, Dulce Brito, Rui Cernadas, Jonathan dos Santos, Adelino Leite-MoreiraLino Gonçalves, Jorge Ferreira, Carlos Aguiar, Manuela Fonseca, Ricardo Fontes-Carvalho, Fátima Franco, Carolina Lourenço, Elisabete Martins, Hélder Pereira, Mário Santos, Joana Pimenta

^*Corresponding author for this work

Católica Medical School

Research output: Contribution to journal › Review article › peer-review

1 Citation (Scopus)

Abstract

Heart failure (HF) with preserved ejection fraction (HFpEF) affects more than 50% of HF patients worldwide, and more than 70% of HF patients aged over 65. This is a complex syndrome with a clinically heterogeneous presentation and a multifactorial pathophysiology, both of which make its diagnosis and treatment challenging. A Portuguese HF expert panel convened to address HFpEF pathophysiology and therapy, as well as appropriate management within the Portuguese context. This initiative resulted in two position papers that examine the most recently published literature in the field. The present Part I includes a review of the HFpEF literature covering pathophysiology, clinical presentation, diagnosis and treatment, including pharmacological and non-pharmacological strategies. Part II, the second paper, addresses the development of a holistic and integrated HFPEF clinical care system within the Portuguese context that is capable of reducing morbidity and mortality and improving patients’ functional capacity and quality of life.

Translated title of the contribution	Artigo de posicionamento de peritos portugueses sobre a gestão da ICFEp – parte I: fisiopatologia, diagnóstico e tratamento
Original language	English
Pages (from-to)	233-243
Number of pages	11
Journal	Revista Portuguesa de Cardiologia
Volume	44
Issue number	4
DOIs	https://doi.org/10.1016/j.repc.2024.11.011
Publication status	Published - Apr 2025

Keywords

Diagnosis
Heart failure
Heart failure with preserved ejection fraction
HFpEF
Pathophysiology
Treatment

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Cite this

Silva-Cardoso, J., Moreira, E., Melo, R. T. D., Moraes-Sarmento, P., Cardim, N., Oliveira, M., Gavina, C., Moura, B., Araújo, I., Santos, P., Peres, M., Fonseca, C., Ferreira, J. P., Marques, I., Andrade, A., Baptista, R., Brito, D., Cernadas, R., Santos, J. D., ... Pimenta, J. (2025). A Portuguese expert panel position paper on the management of heart failure with preserved ejection fraction - part I: pathophysiology, diagnosis and treatment. Revista Portuguesa de Cardiologia, 44(4), 233-243. https://doi.org/10.1016/j.repc.2024.11.011

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title = "A Portuguese expert panel position paper on the management of heart failure with preserved ejection fraction - part I: pathophysiology, diagnosis and treatment",

abstract = "Heart failure (HF) with preserved ejection fraction (HFpEF) affects more than 50% of HF patients worldwide, and more than 70% of HF patients aged over 65. This is a complex syndrome with a clinically heterogeneous presentation and a multifactorial pathophysiology, both of which make its diagnosis and treatment challenging. A Portuguese HF expert panel convened to address HFpEF pathophysiology and therapy, as well as appropriate management within the Portuguese context. This initiative resulted in two position papers that examine the most recently published literature in the field. The present Part I includes a review of the HFpEF literature covering pathophysiology, clinical presentation, diagnosis and treatment, including pharmacological and non-pharmacological strategies. Part II, the second paper, addresses the development of a holistic and integrated HFPEF clinical care system within the Portuguese context that is capable of reducing morbidity and mortality and improving patients{\textquoteright} functional capacity and quality of life.",

keywords = "Diagnosis, Heart failure, Heart failure with preserved ejection fraction, HFpEF, Pathophysiology, Treatment, Insufici{\^e}ncia card{\'i}aca, Insufici{\^e}ncia card{\'i}aca com fra{\c c}{\~a}o de eje{\c c}{\~a}o preservada, ICEp, Fisiopatologia, Diagn{\'o}stico, Tratamento",

author = "Jos{\'e} Silva-Cardoso and Em{\'i}lia Moreira and Melo, {Rachel Tavares de} and Pedro Moraes-Sarmento and Nuno Cardim and M{\'a}rio Oliveira and Cristina Gavina and Brenda Moura and In{\^e}s Ara{\'u}jo and Paulo Santos and Marisa Peres and C{\^a}ndida Fonseca and Ferreira, {Jo{\~a}o Pedro} and Irene Marques and Aurora Andrade and Rui Baptista and Dulce Brito and Rui Cernadas and Santos, {Jonathan dos} and Adelino Leite-Moreira and Lino Gon{\c c}alves and Jorge Ferreira and Carlos Aguiar and Manuela Fonseca and Ricardo Fontes-Carvalho and F{\'a}tima Franco and Carolina Louren{\c c}o and Elisabete Martins and H{\'e}lder Pereira and M{\'a}rio Santos and Joana Pimenta",

note = "Publisher Copyright: {\textcopyright} 2025",

year = "2025",

month = apr,

doi = "10.1016/j.repc.2024.11.011",

language = "English",

volume = "44",

pages = "233--243",

journal = "Revista Portuguesa de Cardiologia",

issn = "0870-2551",

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Silva-Cardoso, J, Moreira, E, Melo, RTD, Moraes-Sarmento, P, Cardim, N, Oliveira, M, Gavina, C, Moura, B, Araújo, I, Santos, P, Peres, M, Fonseca, C, Ferreira, JP, Marques, I, Andrade, A, Baptista, R, Brito, D, Cernadas, R, Santos, JD, Leite-Moreira, A, Gonçalves, L, Ferreira, J, Aguiar, C, Fonseca, M, Fontes-Carvalho, R, Franco, F, Lourenço, C, Martins, E, Pereira, H, Santos, M & Pimenta, J 2025, 'A Portuguese expert panel position paper on the management of heart failure with preserved ejection fraction - part I: pathophysiology, diagnosis and treatment', Revista Portuguesa de Cardiologia, vol. 44, no. 4, pp. 233-243. https://doi.org/10.1016/j.repc.2024.11.011

A Portuguese expert panel position paper on the management of heart failure with preserved ejection fraction - part I: pathophysiology, diagnosis and treatment. / Silva-Cardoso, José; Moreira, Emília; Melo, Rachel Tavares de et al.
In: Revista Portuguesa de Cardiologia, Vol. 44, No. 4, 04.2025, p. 233-243.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - A Portuguese expert panel position paper on the management of heart failure with preserved ejection fraction - part I

T2 - pathophysiology, diagnosis and treatment

AU - Silva-Cardoso, José

AU - Moreira, Emília

AU - Melo, Rachel Tavares de

AU - Moraes-Sarmento, Pedro

AU - Cardim, Nuno

AU - Oliveira, Mário

AU - Gavina, Cristina

AU - Moura, Brenda

AU - Araújo, Inês

AU - Santos, Paulo

AU - Peres, Marisa

AU - Fonseca, Cândida

AU - Ferreira, João Pedro

AU - Marques, Irene

AU - Andrade, Aurora

AU - Baptista, Rui

AU - Brito, Dulce

AU - Cernadas, Rui

AU - Santos, Jonathan dos

AU - Leite-Moreira, Adelino

AU - Gonçalves, Lino

AU - Ferreira, Jorge

AU - Aguiar, Carlos

AU - Fonseca, Manuela

AU - Fontes-Carvalho, Ricardo

AU - Franco, Fátima

AU - Lourenço, Carolina

AU - Martins, Elisabete

AU - Pereira, Hélder

AU - Santos, Mário

AU - Pimenta, Joana

PY - 2025/4

Y1 - 2025/4

N2 - Heart failure (HF) with preserved ejection fraction (HFpEF) affects more than 50% of HF patients worldwide, and more than 70% of HF patients aged over 65. This is a complex syndrome with a clinically heterogeneous presentation and a multifactorial pathophysiology, both of which make its diagnosis and treatment challenging. A Portuguese HF expert panel convened to address HFpEF pathophysiology and therapy, as well as appropriate management within the Portuguese context. This initiative resulted in two position papers that examine the most recently published literature in the field. The present Part I includes a review of the HFpEF literature covering pathophysiology, clinical presentation, diagnosis and treatment, including pharmacological and non-pharmacological strategies. Part II, the second paper, addresses the development of a holistic and integrated HFPEF clinical care system within the Portuguese context that is capable of reducing morbidity and mortality and improving patients’ functional capacity and quality of life.

AB - Heart failure (HF) with preserved ejection fraction (HFpEF) affects more than 50% of HF patients worldwide, and more than 70% of HF patients aged over 65. This is a complex syndrome with a clinically heterogeneous presentation and a multifactorial pathophysiology, both of which make its diagnosis and treatment challenging. A Portuguese HF expert panel convened to address HFpEF pathophysiology and therapy, as well as appropriate management within the Portuguese context. This initiative resulted in two position papers that examine the most recently published literature in the field. The present Part I includes a review of the HFpEF literature covering pathophysiology, clinical presentation, diagnosis and treatment, including pharmacological and non-pharmacological strategies. Part II, the second paper, addresses the development of a holistic and integrated HFPEF clinical care system within the Portuguese context that is capable of reducing morbidity and mortality and improving patients’ functional capacity and quality of life.

KW - Diagnosis

KW - Heart failure

KW - Heart failure with preserved ejection fraction

KW - HFpEF

KW - Pathophysiology

KW - Treatment

KW - Insuficiência cardíaca

KW - Insuficiência cardíaca com fração de ejeção preservada

KW - ICEp

KW - Fisiopatologia

KW - Diagnóstico

KW - Tratamento

UR - http://www.scopus.com/inward/record.url?scp=105001569508&partnerID=8YFLogxK

U2 - 10.1016/j.repc.2024.11.011

DO - 10.1016/j.repc.2024.11.011

M3 - Review article

C2 - 39978763

AN - SCOPUS:105001569508

SN - 0870-2551

VL - 44

SP - 233

EP - 243

JO - Revista Portuguesa de Cardiologia

JF - Revista Portuguesa de Cardiologia

IS - 4

ER -

A Portuguese expert panel position paper on the management of heart failure with preserved ejection fraction - part I: pathophysiology, diagnosis and treatment

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Keywords

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