TY - JOUR
T1 - A review on antifungal activity of mushroom (basidiomycetes) extracts and isolated compounds
AU - Alves, Maria José
AU - Ferreira, Isabel C. F. R.
AU - Dias, Joana
AU - Teixeira, Vânia
AU - Martins, Anabela
AU - Pintado, Manuela
N1 - Funding Information:
The authors are grateful to Fundação para a Ciência e a Tecnologia (FCT, Portugal) and COMPETE/QREN/EU for financial support to this work (research project PTDC/AGR-ALI/110062/2009; strategic projects PEst-OE/AGR/ UI0690/2011 and PEst-OE/EQB/LA0016/2011). They also thank to CHTMAD – Hospital Center of Trás-os-Montes e Alto Douro and Siemens for all the support.
Publisher Copyright:
© 2013 Bentham Science Publishers.
PY - 2013
Y1 - 2013
N2 - The present review reports the antifungal activity of mushroom extracts and isolated compounds including high (e.g. peptides and proteins) and low (e.g. sesquiterpenes and other terpenes, steroids, organic acids, acylcyclopentenediones and quinolines) molecular weight compounds. Most of the studies available on literature focused on screening of antifungal activity of mushroom extracts, rather than of isolated compounds. Data indicate that mushroom extracts are mainly tested against different Candida species, while mushroom compounds are mostly tested upon other fungi. Therefore, the potential of these compounds might be more useful in food industry than in clinics. Oudemansiella canarii and Agaricus bisporus methanolic extracts proved to be the most active mushroom extracts against Candida spp. Grifolin, isolated from Albatrellus dispansus, seemed to be the most active compound against phytopathogenic fungi. Further studies should be performed in order to better understand the mechanism of action of this and other antifungal compounds as well as safety issues.
AB - The present review reports the antifungal activity of mushroom extracts and isolated compounds including high (e.g. peptides and proteins) and low (e.g. sesquiterpenes and other terpenes, steroids, organic acids, acylcyclopentenediones and quinolines) molecular weight compounds. Most of the studies available on literature focused on screening of antifungal activity of mushroom extracts, rather than of isolated compounds. Data indicate that mushroom extracts are mainly tested against different Candida species, while mushroom compounds are mostly tested upon other fungi. Therefore, the potential of these compounds might be more useful in food industry than in clinics. Oudemansiella canarii and Agaricus bisporus methanolic extracts proved to be the most active mushroom extracts against Candida spp. Grifolin, isolated from Albatrellus dispansus, seemed to be the most active compound against phytopathogenic fungi. Further studies should be performed in order to better understand the mechanism of action of this and other antifungal compounds as well as safety issues.
UR - http://www.scopus.com/inward/record.url?scp=84903278890&partnerID=8YFLogxK
U2 - 10.2174/15680266113136660191
DO - 10.2174/15680266113136660191
M3 - Review article
C2 - 24083794
AN - SCOPUS:84903278890
SN - 1568-0266
VL - 13
SP - 2648
EP - 2659
JO - Current Topics in Medicinal Chemistry
JF - Current Topics in Medicinal Chemistry
IS - 21
ER -