TY - JOUR
T1 - A study of the bioactive potential of seven neglected and underutilized leaves consumed in Brazil
AU - Souza, Thais Cristina Lima de
AU - Silveira, Tayse Ferreira Ferreira da
AU - Rodrigues, Maria Isabel
AU - Ruiz, Ana Lucia Tasca Gois
AU - Neves, Daniela Andrade
AU - Duarte, Marta Cristina Teixeira
AU - Cunha-Santos, Elenice Carla Emidio
AU - Kuhnle, Gunter
AU - Ribeiro, Alessandra Braga
AU - Godoy, Helena Teixeira
N1 - Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/12/1
Y1 - 2021/12/1
N2 - This study investigated the vitamin C content, total phenolic compounds (TPC), and the potential bioactivities (antioxidant, antiproliferative, antibacterial activities, and inhibition capacity against N-nitrosation) of seven neglected and underutilized species (NUS): culantro (Eryngium foetidum), false roselle (Hibiscus acetosella), roselle (Hibiscus sabdariffa), tree basil (Ocimum gratissimum), Barbados Gooseberry (Pereskia aculeata), purslane (Portulaca oleracea), and tannia (Xanthosoma sagittifolium). Phenolic-rich extracts were obtained by a sequential optimization strategy (Plackett-Burman and Central Composite Design). O. gratissimum presented the highest TPC and X. sagittifolium the greater total vitamin C content. Overall, the plant extracts presented promising bioactive capacities, as scavenging capacity against HOCl, H2O2 and ROO• induced oxidation. P. oleracea demonstrated the highest cytostatic effect against ovarian and kidney tumor cells. O. gratissimum effectively inhibited S. Choleraesuis growth. Maximum inhibition on n-nitrosation was showed by O. gratissimum and E. foetidum. These results highlight the studied NUS as sources of potential health-promoting compounds.
AB - This study investigated the vitamin C content, total phenolic compounds (TPC), and the potential bioactivities (antioxidant, antiproliferative, antibacterial activities, and inhibition capacity against N-nitrosation) of seven neglected and underutilized species (NUS): culantro (Eryngium foetidum), false roselle (Hibiscus acetosella), roselle (Hibiscus sabdariffa), tree basil (Ocimum gratissimum), Barbados Gooseberry (Pereskia aculeata), purslane (Portulaca oleracea), and tannia (Xanthosoma sagittifolium). Phenolic-rich extracts were obtained by a sequential optimization strategy (Plackett-Burman and Central Composite Design). O. gratissimum presented the highest TPC and X. sagittifolium the greater total vitamin C content. Overall, the plant extracts presented promising bioactive capacities, as scavenging capacity against HOCl, H2O2 and ROO• induced oxidation. P. oleracea demonstrated the highest cytostatic effect against ovarian and kidney tumor cells. O. gratissimum effectively inhibited S. Choleraesuis growth. Maximum inhibition on n-nitrosation was showed by O. gratissimum and E. foetidum. These results highlight the studied NUS as sources of potential health-promoting compounds.
KW - Anticancer
KW - Antitumor
KW - Bioactive
KW - NOC
KW - Phenolic optimization
KW - vitamin C
KW - Wild plants
UR - http://www.scopus.com/inward/record.url?scp=85109135299&partnerID=8YFLogxK
U2 - 10.1016/j.foodchem.2021.130350
DO - 10.1016/j.foodchem.2021.130350
M3 - Article
C2 - 34153595
AN - SCOPUS:85109135299
SN - 0308-8146
VL - 364
JO - Food Chemistry
JF - Food Chemistry
M1 - 130350
ER -
