Adenosine-loaded silk fibroin aerogel particles for wound healing

Beatriz G. Bernardes, Valentina Rossa, Sara Baptista-Silva, Rui Magalhães, Raquel Costa*, Carlos A. García-González, Ana Leite Oliveira

*Corresponding author for this work

Research output: Contribution to conferenceAbstractpeer-review

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Abstract

Chronic wounds are one of the major therapeutic and healthcare challenges. A natural healing response is the production of exudate from a wound. However, its overproduction can compromise and delay the inflammatory phase, resulting in chronicity. Bio-based aerogels, from natural polymer sources, can provide advanced performance for wound healing due to their high porosity and large surface area, which can be tailored for a fast and directional fluid transfer of the exudate; also, they can act as carriers for bioactive compounds. Silk fibroin (SF) protein is an excellent carrier of bioactive compounds while supporting cell proliferation, being presently used in wound healing and regeneration. In this work, we propose the use supercritical CO2 technology to develop SF aerogel particles as a controlled release system of adenosine, a protein that is herein proposed for the first time being expected to trigger the healing process of chronic wounds, promoting angiogenesis and regeneration. For the aerogel particles’ production, SF aqueous solutions at different concentrations (3, 5 and 7 %(w/v)) loaded with adenosine at different ratios were dispersed in a solution of ethanol/Span 80 (3 wt.% with respect to SF), followed by supercritical CO2 drying (120 bar, 39ºC, 3.5 h). Physico-chemical characteristics, drug release and cytotoxicity activity of bioactive SF particles will be explored.
Original languageEnglish
Number of pages1
Publication statusPublished - Jun 2022
EventAerogels for Biomedical Applications: Training School - Katholieke Universiteit Leuven, Leuven, Belgium
Duration: 7 Jun 202210 Jun 2022

Workshop

WorkshopAerogels for Biomedical Applications
Country/TerritoryBelgium
CityLeuven
Period7/06/2210/06/22
OtherAerogels are a special class of nanostructured materials with very high porosity and tunable physicochemical properties. Research in aerogels is a rapidly growing multidisciplinary field combining engineering, chemistry, physics, medicine, life sciences and including regenerative medicine and tissue engineering. In this training school we will share presentations of experts working with fabrication and characterization, pharmaceutical applications, tissue engineering and regenerative medicine, biomaterials, scaffolds, and cell-surface interactions. It is a unique opportunity to discover and exploit the new frontiers of this exciting field and to highlight the relevance of Aerogels expertise of Aerogels-COST partners to advance the state of the art of materials for biomedical applications. Joint contribution of European Polysaccharide Network of Excellence (EPNOE) will also be possible.

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