Adiponectin is an independent predictor of tissue plasminogen activator levels in patients under haemodialysis

Maria do Sameiro Faria, Sandra Ribeiro, Henrique Nascimento, Petronila Rocha-Pereira, Vasco Miranda, Denisa Mendonça, Alexandre Quintanilha, Elísio Costa, Luís Belo, Alice Santos-Silva*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objective. The aim of this study was to evaluate the association of tissue-type plasminogen activator (t-PA) levels with clinical data of patients under haemodialysis (HD) and with several variables potentially related to endothelial function and dysfunction. Material and methods. In a cross-sectional study involving 189 Portuguese HD patients, circulating levels of t-PA, lipids, oxidized low-density lipoprotein (Ox-LDL), interleukin-6 (IL-6), C-reactive protein (CRP), adiponectin, plasminogen activator inhibitor type 1 (PAI-1) and fibrin fragment D-dimer were measured. Results. Considering the entire population, t-PA correlated inversely and significantly with adiponectin and high-density lipoprotein-cholesterol, and positively and significantly with age, body mass index, PAI-1, IL-6, CRP, D-dimer, cholesterol and Ox-LDL. In multiple linear regression analysis PAI-1, age and adiponectin remained statistically associated with t-PA values (p < 0.01 for all). The weakest significant association (p = 0.046) was that found between t-PA and D-dimer. Conclusion. Adiponectin is a main determinant of t-PA level, which may be a good marker of endothelial dysfunction in HD patients.
Original languageEnglish
Pages (from-to)461-465
Number of pages5
JournalScandinavian Journal of Urology and Nephrology
Issue number6
Publication statusPublished - Dec 2012


  • Adiponectin
  • Haemodialysis
  • Inflammation
  • Tissue plasminogen activator


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