Aging and cognitive decline: neuroprotective strategies

Frederico Simões do Couto; Alexandre de Mendonça

doi:10.1007/978-0-387-70830-0_11

Aging and cognitive decline: neuroprotective strategies

Frederico Simões do Couto, Alexandre de Mendonça

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Citation (Scopus)

Abstract

Neuronal loss occurs with aging or dementia, and an extended concept of neuroprotection assumes that the administration of a drug, or a procedure, is able to reverse or prevent neuronal damage. Neuroprotective strategies have been classified according to the mechanisms of neuronal death, and this chapter will deal mainly with neuroinflammation and related processes that occur in aging, cognitive decline, and dementia. The evidence for inflammatory phenomena in dementia, especially in Alzheimer's disease (AD), is impressive, and the role of inflammatory cells and mediators has been extensively studied. Furthermore, anti-inflammatory drugs (specially the nonsteroidal anti-inflammatory drugs (NSAIDs)) have been shown to attenuate these phenomena in preclinical studies.

Original language	English
Title of host publication	Interaction Between Neurons and Glia in Aging and Disease
Editors	João O. Malva, Ana C. Rego, Rodrigo A. Cunha, Catarina R. Oliveira
Place of Publication	Boston
Publisher	Springer US
Pages	245-268
Number of pages	24
ISBN (Electronic)	9780387708300
ISBN (Print)	9780387708294
DOIs	https://doi.org/10.1007/978-0-387-70830-0_11
Publication status	Published - 2007
Externally published	Yes

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10.1007/978-0-387-70830-0_11

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Aging and cognitive decline: neuroprotective strategies. / Couto, Frederico Simões do; Mendonça, Alexandre de.
Interaction Between Neurons and Glia in Aging and Disease. ed. / João O. Malva; Ana C. Rego; Rodrigo A. Cunha; Catarina R. Oliveira . Boston: Springer US, 2007. p. 245-268.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

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Aging and cognitive decline: neuroprotective strategies

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