Allergic inflammation triggers dyslipidemia via IgG signalling

Nieves Fernández-Gallego, Raquel Castillo-González, Lucía Moreno-Serna, Antonio J. García-Cívico, Elisa Sánchez-Martínez, Celia López-Sanz, Ana Luiza Fontes, Lígia L. Pimentel, Ana Gradillas, David Obeso, René Neuhaus, Marta Ramírez-Huesca, Ignacio Ruiz-Fernández, Emilio Nuñez-Borque, Yolanda R. Carrasco, Borja Ibáñez, Pilar Martín, Carlos Blanco, Coral Barbas, Domingo BarberLuis M. Rodríguez-Alcalá, Alma Villaseñor, Vanesa Esteban, Francisco Sánchez-Madrid, Rodrigo Jiménez-Saiz*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Allergic diseases begin early in life and are often chronic, thus creating an inflammatory environment that may precede or exacerbate other pathologies. In this regard, allergy has been associated to metabolic disorders and with a higher risk of cardiovascular disease, but the underlying mechanisms remain incompletely understood. Methods: We used a murine model of allergy and atherosclerosis, different diets and sensitization methods, and cell-depleting strategies to ascertain the contribution of acute and late phase inflammation to dyslipidemia. Untargeted lipidomic analyses were applied to define the lipid fingerprint of allergic inflammation at different phases of allergic pathology. Expression of genes related to lipid metabolism was assessed in liver and adipose tissue at different times post-allergen challenge. Also, changes in serum triglycerides (TGs) were evaluated in a group of 59 patients ≥14 days after the onset of an allergic reaction. Results: We found that allergic inflammation induces a unique lipid signature that is characterized by increased serum TGs and changes in the expression of genes related to lipid metabolism in liver and adipose tissue. Alterations in blood TGs following an allergic reaction are independent of T-cell-driven late phase inflammation. On the contrary, the IgG-mediated alternative pathway of anaphylaxis is sufficient to induce a TG increase and a unique lipid profile. Lastly, we demonstrated an increase in serum TGs in 59 patients after undergoing an allergic reaction. Conclusion: Overall, this study reveals that IgG-mediated allergic inflammation regulates lipid metabolism.

Original languageEnglish
JournalAllergy: European Journal of Allergy and Clinical Immunology
DOIs
Publication statusAccepted/In press - 2024

Keywords

  • Allergic inflammation
  • Cardiovascular risk
  • Dyslipidemia
  • IgG
  • Lipidomics
  • Metabolism

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