@article{c1b0025f035f4e64a8f2a2faaf3a26d7,
title = "An alignment-free method to find and visualise rearrangements between pairs of DNA sequences",
abstract = "Species evolution is indirectly registered in their genomic structure. The emergence and advances in sequencing technology provided a way to access genome information, namely to identify and study evolutionary macro-events, as well as chromosome alterations for clinical purposes. This paper describes a completely alignment-free computational method, based on a blind unsupervised approach, to detect large-scale and small-scale genomic rearrangements between pairs of DNA sequences. To illustrate the power and usefulness of the method we give complete chromosomal information maps for the pairs human-chimpanzee and human-orangutan. The tool by means of which these results were obtained has been made publicly available and is described in detail.",
author = "Diogo Pratas and Silva, {Raquel M.} and Pinho, {Armando J.} and Ferreira, {Paulo J. S. G.}",
note = "Funding Information: Supported by the European Fund for Regional Development (FEDER) through the Operational Program Competitiveness Factors (COMPETE) and by the Portuguese Foundation for Science and Technology (FCT), in the context of projects PEst-OE/EEI/UI0127/2014 and Incentivo/EEI/UI0127/2014. DP is supported by the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement No. 305444 “RD-Connect: An integrated platform connecting registries, biobanks and clinical bioinformatics for rare disease research”. RMS is supported by the project Neuropath (CENTRO-07-ST24-FEDER-002034), co-funded by QREN Mais Centro program and the EU. Publisher Copyright: {\textcopyright} 2015, Nature Publishing Group. All rights reserved. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.",
year = "2015",
month = may,
day = "18",
doi = "10.1038/srep10203",
language = "English",
volume = "5",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
}