@article{11d4259d46324580b50c69c1be02be30,
title = "An insight into the synthesis of cationic porphyrin-imidazole derivatives and their photodynamic inactivation efficiency against Escherichia coli",
abstract = "New porphyrin-imidazole derivatives were synthesised by Radziszewski reaction between 2-formyl-5,10,15,20-tetraphenylporphyrin 1 and several (hetero)aromatic 1,2-diones, which after cationization afforded promising monocationic photosensitizers 3a-d. Singlet oxygen studies have demonstrated that all the cationic porphyrin-imidazole conjugates 3a–d were capable to produce cytotoxic species. These photosensitizers were able to photoinactivate Eschericha coli and their inactivation profile was improved in the presence of KI.",
keywords = "Antimicrobial photodynamic therapy, Gram-negative E. coli, N-Heterocycles, Photosensitizer, Porphyrin",
author = "Xavier Moreira and Patr{\'i}cia Santos and Faustino, {M. Amparo F.} and Raposo, {M. Manuela M.} and Costa, {Susana P. G.} and Moura, {Nuno M.M.} and Gomes, {Ana T. P. C.} and Adelaide Almeida and Neves, {M. G. P. M. S.}",
note = "Funding Information: The authors are grateful to University of Aveiro and FCT / MCT for the financial support for QOPNA research Unit ( FCT UID/QUI/00062/2019 ), the LAQV-REQUIMTE ( UIDB/50006/2020 ), CESAM ( UID/AMB/50017/2019 ) and CQUM ( QUI/UI0686/2018 ) through national founds and, where applicable, co-financed by the FEDER , within the PT2020 Partnership Agreement, and to the Portuguese NMR Network. The research contract of N.M.M. Moura ( REF.-048-88-ARH/2018 ) is funded by national funds (OE) , through FCT – Funda{\c c}{\~a}o para a Ci{\^e}ncia e a Tecnologia , I.P., in the scope of the framework contract foreseen in the numbers 4, 5 and 6 of the article 23, of the Decree-Law 57/2016, of August 29, changed by Law 57/2017, of July 19. Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",
year = "2020",
month = jul,
doi = "10.1016/j.dyepig.2020.108330",
language = "English",
volume = "178",
journal = "Dyes and Pigments",
issn = "0143-7208",
publisher = "Elsevier B.V.",
}