TY - JOUR
T1 - Antibiotic resistance genes in the human-impacted environment
T2 - a one health perspective
AU - Tiedje, James M.
AU - Wang, Fang
AU - Manaia, Célia M.
AU - Virta, Marko
AU - Sheng, Hongjie
AU - Ma, Liping
AU - Zhang, Tong
AU - Topp, Edward
PY - 2019/6
Y1 - 2019/6
N2 - Antibiotic resistance and its environmental component are gaining more attention as part of combating the growing healthcare crisis. The One Health framework, promulgated by many global health agencies, recognizes that antimicrobial resistance is a truly inter-domain problem in which human health, animal agriculture, and the environment are the core and interrelated components. This prospectus presents the status and issues relevant to the environmental component of antibiotic resistance, namely, the needs for advancing surveillance methodology: the environmental reservoirs and sources of resistance, namely, urban wastewater treatment plants, aquaculture production systems, soil receiving manure and biosolid, and the atmosphere which includes longer range dispersal. Recently, much work has been done describing antibiotic resistance genes in various environments; now quantitative, mechanistic, and hypothesis-driven studies are needed to identify practices that reduce real risks and maintain the effectiveness of our current antibiotics as long as possible. Advanced deployable detection methods for antibiotic resistance in diverse environmental samples are needed in order to provide the surveillance information to identify risks and define barriers that can reduce risks. Also needed are practices that reduce antibiotic use and thereby reduce selection for resistance, as well as practices that limit the dispersal of or destroy antibiotic-resistant bacteria or their resistance genes that are feasible for these varied environmental domains.
AB - Antibiotic resistance and its environmental component are gaining more attention as part of combating the growing healthcare crisis. The One Health framework, promulgated by many global health agencies, recognizes that antimicrobial resistance is a truly inter-domain problem in which human health, animal agriculture, and the environment are the core and interrelated components. This prospectus presents the status and issues relevant to the environmental component of antibiotic resistance, namely, the needs for advancing surveillance methodology: the environmental reservoirs and sources of resistance, namely, urban wastewater treatment plants, aquaculture production systems, soil receiving manure and biosolid, and the atmosphere which includes longer range dispersal. Recently, much work has been done describing antibiotic resistance genes in various environments; now quantitative, mechanistic, and hypothesis-driven studies are needed to identify practices that reduce real risks and maintain the effectiveness of our current antibiotics as long as possible. Advanced deployable detection methods for antibiotic resistance in diverse environmental samples are needed in order to provide the surveillance information to identify risks and define barriers that can reduce risks. Also needed are practices that reduce antibiotic use and thereby reduce selection for resistance, as well as practices that limit the dispersal of or destroy antibiotic-resistant bacteria or their resistance genes that are feasible for these varied environmental domains.
KW - Animal agriculture
KW - Antibiotic-resistant bacteria
KW - Antimicrobial resistance
KW - Aquaculture
KW - Human health
KW - One health framework
KW - Soil contamination
KW - Wastewater and sludge
UR - http://www.scopus.com/inward/record.url?scp=85065650833&partnerID=8YFLogxK
U2 - 10.1016/S1002-0160(18)60062-1
DO - 10.1016/S1002-0160(18)60062-1
M3 - Article
AN - SCOPUS:85065650833
SN - 1002-0160
VL - 29
SP - 273
EP - 282
JO - Pedosphere
JF - Pedosphere
IS - 3
ER -