TY - JOUR
T1 - Antioxidant and anti-cholinesterase activities of Lavandula viridis L'Hér extracts after in vitro gastrointestinal digestion
AU - Costa, Patrícia
AU - Grevenstuk, Tomás
AU - Rosa da Costa, Ana M.
AU - Gonçalves, Sandra
AU - Romano, Anabela
N1 - Funding Information:
P. Costa, T. Grevenstuk and S. Gonçalves acknowledge grants from the Portuguese Science and Technology Foundation (FCT) ( SFRH/BD/63505/2009 , SFRH/BPD/73293/2010 and SFRH/BPD/31534/2006 , respectively).
PY - 2014/4
Y1 - 2014/4
N2 - Lavandula viridis L'Hér is an aromatic shrub with relevant biological activities associated to the presence of phenolic compounds. However, these compounds must be bioavailable to exert their biological function. Therefore, in this study, we investigated the influence of the L. viridis extract matrices on the digestion of the main component rosmarinic acid and their antioxidant and anti-cholinesterase activities after in vitro gastrointestinal digestion. Overall, the antioxidant and anti-cholinesterase activities were assured after in vitro gastrointestinal processes and we observed that the L. viridis extract matrices have an important role in the bioactive effects of their main compound, rosmarinic acid. The L. viridis extracts and rosmarinic acid did not show any toxic effect on colon adenocarcinoma Caco-2 cell viability. Finally, the compounds from L. viridis extracts were not metabolized by Caco-2 cells and were not able to permeate into them.
AB - Lavandula viridis L'Hér is an aromatic shrub with relevant biological activities associated to the presence of phenolic compounds. However, these compounds must be bioavailable to exert their biological function. Therefore, in this study, we investigated the influence of the L. viridis extract matrices on the digestion of the main component rosmarinic acid and their antioxidant and anti-cholinesterase activities after in vitro gastrointestinal digestion. Overall, the antioxidant and anti-cholinesterase activities were assured after in vitro gastrointestinal processes and we observed that the L. viridis extract matrices have an important role in the bioactive effects of their main compound, rosmarinic acid. The L. viridis extracts and rosmarinic acid did not show any toxic effect on colon adenocarcinoma Caco-2 cell viability. Finally, the compounds from L. viridis extracts were not metabolized by Caco-2 cells and were not able to permeate into them.
KW - Anti-cholinesterase activity
KW - Antioxidant activity
KW - In vitro digestion
KW - Lavandula viridis
KW - Rosmarinic acid
UR - http://www.scopus.com/inward/record.url?scp=84896748759&partnerID=8YFLogxK
U2 - 10.1016/j.indcrop.2014.01.049
DO - 10.1016/j.indcrop.2014.01.049
M3 - Article
AN - SCOPUS:84896748759
SN - 0926-6690
VL - 55
SP - 83
EP - 89
JO - Industrial Crops and Products
JF - Industrial Crops and Products
ER -