Antiulcerogenic activity of peptide concentrates obtained from hydrolysis of whey proteins by proteases from Cynara cardunculus

T. G. Tavares, K. M. Monteiro, A. Possenti, M. E. Pintado, J. E. Carvalho, F. X. Malcata*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Peptide concentrates generated by hydrolysis of whey with aqueous extracts of flowers of Cynara cardunculus were studied for possible protection of the stomach mucosa against ulcerative lesions caused by oral administration of absolute ethanol. Both the whole peptide fraction obtained via hydrolysis of whey protein concentrate (peptide concentrate, PepC) and its fraction below 3kDa (PepCF) were able to reduce gastric injuries to significant levels (p<0.05). Single-dose experiments, using 100mgkg-1 body weight (bw) of either PepCF or PepC, led to 68.5% and 37.4% protection, respectively - which compare well with 93.4% protection by 200mgkg-1bw carbenoxolone (a positive control). No dose-response correlation could be demonstrated. Gastric cytoprotection by PepCF appears to depend on sulphydryl-containing moieties, whereas PepC likely protects the gastric mucosa via the prostaglandin cycle and production of nitric oxide.
Original languageEnglish
Pages (from-to)934-939
Number of pages6
JournalInternational Dairy Journal
Volume21
Issue number12
DOIs
Publication statusPublished - Dec 2011

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