TY - JOUR
T1 - Apolipoprotein E genotype does not influence the risk of symptomatic hemorrhage in acute ischemic stroke
AU - Tábuas-Pereira, Miguel
AU - Galego, Orlando
AU - Almeida, Maria Rosário
AU - Tomás, José
AU - Félix-Morais, Ricardo
AU - Silva, Fernando
AU - Rodrigues, Bruno
AU - Cordeiro, Gustavo
AU - Sargento-Freitas, João
N1 - Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/6
Y1 - 2021/6
N2 - Background: APOE ε4 is independently associated with lobar intracranial hemorrhages (ICH). Although the ε4 allele enhances amyloid deposition in blood vessels, the ε2 allele predisposes to vasculopathic changes leading to rupture of amyloid laden vessels. Thus, ε4 and ε2 carriers might have increased susceptibility to ICH. We aimed to study the impact of the apolipoprotein E alleles in the development of symptomatic ICH (sICH). Methods: We included 384 consecutive ischemic anterior circulation stroke patients submitted to thrombolysis between January 2014 and March 2016. Admission CT-scans were reviewed to calculate the ASPECTS. Patients were followed for up to at least 6 months post-stroke or until death. Outcome was development of sICH, defined according to the ECASS III. Results: Considering APOE genotyping, three patients had ε2/ε2, four had ε2/ε4, 38 had ε2/ε3, 284 had ε3/ε3, 51 had ε3/ε4 and four had ε4/ε4. sICH was associated with sex and diabetes. In multivariate analysis, sICH was not associated with carrying one or more ε4 alleles (OR: 0.483, 95%CI = [0.059, 3.939], p = 0.497) nor with carrying one or more ε2 alleles (OR: 1.369, 95%CI = [0.278, 6.734], p = 0.699). Conclusion: No association was found between APOE genotype and the development of symptomatic intracranial hemorrhage.
AB - Background: APOE ε4 is independently associated with lobar intracranial hemorrhages (ICH). Although the ε4 allele enhances amyloid deposition in blood vessels, the ε2 allele predisposes to vasculopathic changes leading to rupture of amyloid laden vessels. Thus, ε4 and ε2 carriers might have increased susceptibility to ICH. We aimed to study the impact of the apolipoprotein E alleles in the development of symptomatic ICH (sICH). Methods: We included 384 consecutive ischemic anterior circulation stroke patients submitted to thrombolysis between January 2014 and March 2016. Admission CT-scans were reviewed to calculate the ASPECTS. Patients were followed for up to at least 6 months post-stroke or until death. Outcome was development of sICH, defined according to the ECASS III. Results: Considering APOE genotyping, three patients had ε2/ε2, four had ε2/ε4, 38 had ε2/ε3, 284 had ε3/ε3, 51 had ε3/ε4 and four had ε4/ε4. sICH was associated with sex and diabetes. In multivariate analysis, sICH was not associated with carrying one or more ε4 alleles (OR: 0.483, 95%CI = [0.059, 3.939], p = 0.497) nor with carrying one or more ε2 alleles (OR: 1.369, 95%CI = [0.278, 6.734], p = 0.699). Conclusion: No association was found between APOE genotype and the development of symptomatic intracranial hemorrhage.
KW - Apolipoprotein
KW - Apolipoprotein E
KW - Hemorrhage
KW - Ischemic
KW - Stroke
KW - Thrombolysis
KW - Vessel
UR - http://www.scopus.com/inward/record.url?scp=85103413374&partnerID=8YFLogxK
U2 - 10.1016/j.jocn.2021.03.014
DO - 10.1016/j.jocn.2021.03.014
M3 - Article
C2 - 33992200
AN - SCOPUS:85103413374
SN - 0967-5868
VL - 88
SP - 34
EP - 38
JO - Journal of Clinical Neuroscience
JF - Journal of Clinical Neuroscience
ER -