Application of a fiber optic refractometric sensor to measure the concentration of paracetamol in crystallization experiments

Liliana Soares*, Patricia Cruz, Susana Novais, Antonio Ferreira, Orlando Frezao, Susana Silva

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

A refractometric sensor was applied to measure in real-time the concentration of Active Pharmaceutical Ingredients (APIs) in crystallization experiments. Paracetamol was used as a model system due to the extensive literature available for this API. The refractometric sensor was fabricated by a simple and inexpensive method that consisted in splicing a short section of a multimode fiber to a single mode fiber. The compact geometry of this sensor, with an external diameter of just 125\ \mu\mathrm{m}, allowed it to measure the concentration of paracetamol, both in a stirred tank crystallizer operating in batch and in an oscillatory flow crystallizer operating continuously. The proposed technique shows the potential to monitor the concentration of APIs in crystallizers of different sizes and geometries as an alternative to more expensive and complex analysis equipment.
Original languageEnglish
Article number9491002
Pages (from-to)36-40
Number of pages5
JournalIEEE Instrumentation and Measurement Magazine
Volume24
Issue number5
DOIs
Publication statusPublished - Aug 2021
Externally publishedYes

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