Application of Bonelike® as synthetic bone graft in orthopaedic and oral surgery in veterinary clinical cases

José Miguel Campos, Ana Catarina Sousa, Pedro Olivério Pinto, Jorge Ribeiro, Miguel Lacueva França, Ana Rita Caseiro, Mariana Vieira Branquinho, Sílvia Santos Pedrosa, Carla Mendonça, Ana Brandão, José Domingos Santos, Américo Afonso, Luís Miguel Atayde, Ana Lúcia Luís, Ana Colette Maurício*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Autologous bone remains the gold standard grafting substrate for bone fusions used for small gaps and critical defects. However, significant morbidity is associated with the harvesting of autologous bone grafts and, for that reason, alternative bone graft substitutes have been developed. In the present case series, a glass-reinforced hydroxyapatite synthetic bone substitute, with osteoinductive and osteoconductive proprieties, was applied. This synthetic bone substitute comprises the incorporation of P 2 O 5 -CaO glass-based system within a hydroxyapatite matrix, moulded into spherical pellets with 250-500 μm of diameter. A total of 14 veterinary clinical cases of appendicular bone defects and maxillary / mandibular bone defects are described. In all clinical cases, the synthetic bone substitute was used to fill bone defects, enhancing bone regeneration and complementing the recommended surgical techniques. Results demonstrated that it is an appropriate synthetic bone graft available to be used in veterinary patients. It functioned as a space filler in association with standard orthopaedic and odontological procedures of stabilization, promoting a faster bone fusion without any local or systemic adverse reactions. This procedure improves the animals' quality of life, decreasing pain and post-operative recovery period, as well as increasing bone stability improving positive clinical outcomes.

Original languageEnglish
Article number38
JournalBiomaterials Research
Issue number1
Publication statusPublished - 29 Dec 2018
Externally publishedYes


  • And odontology
  • Biomaterial
  • Bone regeneration
  • Bonelike®
  • Canine
  • Case series
  • Feline
  • Orthopaedics
  • Synthetic bone graft
  • Veterinary


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