Archaeosomes for skin injuries

Monica Vazzana, Joana F. Fangueiro, Caterina Faggio, Antonello Santini, Eliana B. Souto

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

4 Citations (Scopus)

Abstract

Artificially vesicular carriers, such as liposomes, have attracted great interest showing important success in the delivery of drugs, genes, vaccines, and other bioactive agents. In addition, these systems are ideal models for biological membranes, becoming useful tools in diagnostics, targeted cancer, and gene therapy. Archaeosomes are a new generation of liposomes, made from one or more polar ether lipids extracted from natural archaeal membrane lipids or synthetic archaeal lipids, exhibiting higher stability under different conditions, such as high temperatures, alkaline or acidic pH, presence of bile salts that would be encountered in the GI tract, and they are more resistant to oxidation and chemical hydrolysis than liposomes. Although archaeosomes are a recent technology, they have already proven to be a safe delivery system for bioactive compounds. The current challenge of drug delivery is liberation of drug agents at the right time in a safe and reproducible manner to a specific target site.
Original languageEnglish
Title of host publicationCarrier-mediated dermal delivery
Subtitle of host publicationapplications in the prevention and treatment of skin disorders
EditorsAndreia Ascenso, Sandra Simões, Helena Ribeiro
PublisherPan Stanford Publishing Pte. Ltd.
Pages323-355
Number of pages33
ISBN (Electronic)9789814745598
ISBN (Print)9789814745581
DOIs
Publication statusPublished - 1 Jan 2017
Externally publishedYes

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