Are structurally modified galactomannan derivatives biologically active?

Maurycyo Silva Geronço, Igor Frederico da Silveira Ramos, Edson Cavalcanti da Silva Filho, Márcia dos Santos Rizzo, Alessandra Braga Ribeiro*, Marcilia Pinheiro da Costa

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Galactomannans are versatile macromolecules with broad industrial potential. The influence of changes in the chemical structures and respective bioactivities of these polysaccharides have been extensively studied. The derivatives obtained by sulfation, complexation, and phosphorylation are the most studied biological properties in galactomannans. The derivatives obtained have shown several pharmacological activities such as antiviral, antimicrobial, anticoagulant, fibrinolytic, chemopreventive, anticancer, antioxidant, chondroprotective, analgesic, immunomodulatory, and antileishmanial. Considering the relevance of these studies, we aim to provide an overview of studies that apply galactomannan modification or derivatization strategies to improve their properties for applications in the biomedical area. We identified the success of most modified galactomannans for pharmacological purposes. However, some studies found loss of bioactivity of the original polysaccharide after chemical changes to its original structures.
Original languageEnglish
Number of pages15
JournalPolysaccharides
Volume2
Issue number1
DOIs
Publication statusPublished - 8 Jan 2021

Keywords

  • Polysaccharides
  • Biopolymer
  • Bioactivity
  • Derivatization

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