Are structurally modified galactomannan derivatives biologically active?

Maurycyo Silva Geronço; Igor Frederico da Silveira Ramos; Edson Cavalcanti da Silva Filho; Márcia dos Santos Rizzo; Alessandra Braga Ribeiro; Marcilia Pinheiro da Costa

doi:10.3390/polysaccharides2010001

Are structurally modified galactomannan derivatives biologically active?

Maurycyo Silva Geronço^*, Igor Frederico da Silveira Ramos^*, Edson Cavalcanti da Silva Filho^*, Márcia dos Santos Rizzo^*, Alessandra Braga Ribeiro^*, Marcilia Pinheiro da Costa^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

12 Citations (Scopus)

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Abstract

Galactomannans are versatile macromolecules with broad industrial potential. The influence of changes in the chemical structures and respective bioactivities of these polysaccharides have been extensively studied. The derivatives obtained by sulfation, complexation, and phosphorylation are the most studied biological properties in galactomannans. The derivatives obtained have shown several pharmacological activities such as antiviral, antimicrobial, anticoagulant, fibrinolytic, chemopreventive, anticancer, antioxidant, chondroprotective, analgesic, immunomodulatory, and antileishmanial. Considering the relevance of these studies, we aim to provide an overview of studies that apply galactomannan modification or derivatization strategies to improve their properties for applications in the biomedical area. We identified the success of most modified galactomannans for pharmacological purposes. However, some studies found loss of bioactivity of the original polysaccharide after chemical changes to its original structures.

Original language	English
Pages (from-to)	1-15
Number of pages	15
Journal	Polysaccharides
Volume	2
Issue number	1
DOIs	https://doi.org/10.3390/polysaccharides2010001
Publication status	Published - 8 Jan 2021

Keywords

Bioactivity
Biopolymer
Derivatization
Polysaccharides

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10.3390/polysaccharides2010001Licence: CC BY

40965224Final published version, 1.04 MBLicence: CC BY

http://hdl.handle.net/10400.14/36690Licence: CC BY

Cite this

@article{edb43c4788604097a27308901b83576b,

title = "Are structurally modified galactomannan derivatives biologically active?",

abstract = "Galactomannans are versatile macromolecules with broad industrial potential. The influence of changes in the chemical structures and respective bioactivities of these polysaccharides have been extensively studied. The derivatives obtained by sulfation, complexation, and phosphorylation are the most studied biological properties in galactomannans. The derivatives obtained have shown several pharmacological activities such as antiviral, antimicrobial, anticoagulant, fibrinolytic, chemopreventive, anticancer, antioxidant, chondroprotective, analgesic, immunomodulatory, and antileishmanial. Considering the relevance of these studies, we aim to provide an overview of studies that apply galactomannan modification or derivatization strategies to improve their properties for applications in the biomedical area. We identified the success of most modified galactomannans for pharmacological purposes. However, some studies found loss of bioactivity of the original polysaccharide after chemical changes to its original structures.",

keywords = "Bioactivity, Biopolymer, Derivatization, Polysaccharides",

author = "Geron{\c c}o, {Maurycyo Silva} and Ramos, {Igor Frederico da Silveira} and Filho, {Edson Cavalcanti da Silva} and Rizzo, {M{\'a}rcia dos Santos} and Ribeiro, {Alessandra Braga} and Costa, {Marcilia Pinheiro da}",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors.",

year = "2021",

month = jan,

day = "8",

doi = "10.3390/polysaccharides2010001",

language = "English",

volume = "2",

pages = "1--15",

journal = "Polysaccharides",

issn = "2673-4176",