TY - JOUR
T1 - Assessment of baby Bibs. GC-MS screening, migration into saliva and insight of toxicity with QSAR tools
AU - Rajbux, Chandisree
AU - Pereira, Joel
AU - Selbourne, Maria do Céu
AU - Costa-Pinto, Ana Rita
AU - Poças, Fátima
PY - 2020/3
Y1 - 2020/3
N2 - Plastic baby Bibs are, according to the European legislation, food contact materials. Therefore, compositional and migration limits applicable to plastics should be observed. This work aimed at identifying potential migrants in Bibs from European market and determining the migration into artificial saliva. Bibs were subjected to screening analyses (GC-MS). Thirty substances non-authorised in European or Swiss legislation were detected: phthalates, light stabilizers, flame retardants and photoinitiators. Irgacure 184, Cyclohexanone, Tinuvin 770, Isophorone and 9-Octadecenamide, (Z)- were detected in saliva after contact with selected Bibs. The migration values render two samples noncompliant although results should be interpreted with caution given the experimental conditions. In order to gain insight on the toxicity of migrants, QSAR tools were applied. Substances non-evaluated or not-listed were analysed with free software regarding their Cramer class ToxTree and their predicted mutagenicity, carcinogenicity and developmental toxicity (VEGA). Results indicate that surveillance is required: monitoring Bibs'compliance, application of GMPs and traceability.
AB - Plastic baby Bibs are, according to the European legislation, food contact materials. Therefore, compositional and migration limits applicable to plastics should be observed. This work aimed at identifying potential migrants in Bibs from European market and determining the migration into artificial saliva. Bibs were subjected to screening analyses (GC-MS). Thirty substances non-authorised in European or Swiss legislation were detected: phthalates, light stabilizers, flame retardants and photoinitiators. Irgacure 184, Cyclohexanone, Tinuvin 770, Isophorone and 9-Octadecenamide, (Z)- were detected in saliva after contact with selected Bibs. The migration values render two samples noncompliant although results should be interpreted with caution given the experimental conditions. In order to gain insight on the toxicity of migrants, QSAR tools were applied. Substances non-evaluated or not-listed were analysed with free software regarding their Cramer class ToxTree and their predicted mutagenicity, carcinogenicity and developmental toxicity (VEGA). Results indicate that surveillance is required: monitoring Bibs'compliance, application of GMPs and traceability.
KW - Baby bibs
KW - Food contact materials
KW - Migration
KW - NIAS
KW - Plastics
KW - QSAR
KW - Safety evaluation
UR - http://www.scopus.com/inward/record.url?scp=85073811587&partnerID=8YFLogxK
U2 - 10.1016/j.foodcont.2019.106951
DO - 10.1016/j.foodcont.2019.106951
M3 - Article
AN - SCOPUS:85073811587
SN - 0956-7135
VL - 109
JO - Food Control
JF - Food Control
M1 - 106951
ER -