Bacterial nanocellulose membranes loaded with vitamin B-based ionic liquids for dermal care applications

G. Chantereau; M. Sharma; A. Abednejad; C. Vilela; E. M. Costa; M. Veiga; F. Antunes; M. M. Pintado; G. Sèbe; V. Coma; M. G. Freire; C. S. R. Freire; A. J. D. Silvestre

doi:10.1016/j.molliq.2020.112547

Bacterial nanocellulose membranes loaded with vitamin B-based ionic liquids for dermal care applications

G. Chantereau, M. Sharma, A. Abednejad, C. Vilela, E. M. Costa, M. Veiga, F. Antunes, M. M. Pintado, G. Sèbe, V. Coma, M. G. Freire^*, C. S. R. Freire^*, A. J. D. Silvestre

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

The development of innovative bio-based skin care products has received an increased attention in the latter years. In the present work, the synthesis of original active principle ingredients based on ionic liquids (ILs) with cholinium cation and vitamins B anions, followed by their incorporation in bacterial nanocellulose (BC) membranes for topical applications, is reported. Three ILs, namely cholinium nicotinate [Ch][B3], cholinium pantothenate [Ch][B5] and cholinium pyridoxylate [Ch][B6], were synthesized through a metathesis reaction and their structure characterized in detail. Thermal analysis confirmed their denomination as ILs and their high thermal resistance. The solubility of these ILs was higher than their vitamin precursors, especially in the case of [Ch][B3] whose solubility increased 30.6-fold enhancing the bioavailability of this vitamin. The incorporation of ILs in BC led to translucent and homogeneous membranes stable up to 190 °C. ILs acted as plasticizers reducing BC brittleness that facilitated their application on irregular skin regions. Moreover, the re-hydration ability of BC-ILs membranes was improved 2.9 to 4.8-fold in comparison to BC, ensuring adequate hydration for ILs release, while the release of ILs in buffer solutions was more complete and faster than the release of vitamins. Finally, BC-ILs were proven not cytotoxic to skin epithelial cells and thus are suitable materials for skin care applications.

Original language	English
Article number	112547
Number of pages	10
Journal	Journal of Molecular Liquids
Volume	302
DOIs	https://doi.org/10.1016/j.molliq.2020.112547
Publication status	Published - 15 Mar 2020

Keywords

Antioxidant activity
Bacterial nanocellulose
Cholinium-based ILs
Ionic liquids
Skin care applications
Vitamin B

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10.1016/j.molliq.2020.112547

19707068Accepted author manuscript, 775 KBLicence: CC BY-NC-ND

http://hdl.handle.net/10400.14/29350Licence: CC BY-NC-ND

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Chantereau, G., Sharma, M., Abednejad, A., Vilela, C., Costa, E. M., Veiga, M., Antunes, F., Pintado, M. M., Sèbe, G., Coma, V., Freire, M. G., Freire, C. S. R., & Silvestre, A. J. D. (2020). Bacterial nanocellulose membranes loaded with vitamin B-based ionic liquids for dermal care applications. Journal of Molecular Liquids, 302, Article 112547. https://doi.org/10.1016/j.molliq.2020.112547

@article{3d9580aaab2c4da2ac6d0990241a068a,

title = "Bacterial nanocellulose membranes loaded with vitamin B-based ionic liquids for dermal care applications",

abstract = "The development of innovative bio-based skin care products has received an increased attention in the latter years. In the present work, the synthesis of original active principle ingredients based on ionic liquids (ILs) with cholinium cation and vitamins B anions, followed by their incorporation in bacterial nanocellulose (BC) membranes for topical applications, is reported. Three ILs, namely cholinium nicotinate [Ch][B3], cholinium pantothenate [Ch][B5] and cholinium pyridoxylate [Ch][B6], were synthesized through a metathesis reaction and their structure characterized in detail. Thermal analysis confirmed their denomination as ILs and their high thermal resistance. The solubility of these ILs was higher than their vitamin precursors, especially in the case of [Ch][B3] whose solubility increased 30.6-fold enhancing the bioavailability of this vitamin. The incorporation of ILs in BC led to translucent and homogeneous membranes stable up to 190 °C. ILs acted as plasticizers reducing BC brittleness that facilitated their application on irregular skin regions. Moreover, the re-hydration ability of BC-ILs membranes was improved 2.9 to 4.8-fold in comparison to BC, ensuring adequate hydration for ILs release, while the release of ILs in buffer solutions was more complete and faster than the release of vitamins. Finally, BC-ILs were proven not cytotoxic to skin epithelial cells and thus are suitable materials for skin care applications.",

keywords = "Antioxidant activity, Bacterial nanocellulose, Cholinium-based ILs, Ionic liquids, Skin care applications, Vitamin B",

author = "G. Chantereau and M. Sharma and A. Abednejad and C. Vilela and Costa, {E. M.} and M. Veiga and F. Antunes and Pintado, {M. M.} and G. S{\`e}be and V. Coma and Freire, {M. G.} and Freire, {C. S. R.} and Silvestre, {A. J. D.}",

note = "Funding Information: This work was developed within the scope of project CICECO-Aveiro Institute of Materials (FCT Ref. UID/CTM/50011/2019 ), financed by national funds through the FCT / MEC . G. Chantereau thanks the European Joint Doctorate in Functional Materials Research EJD FunMat (Grant agreement ID: 641640) for the PhD fellowship. Laboratoire de Chimie des Polym{\`e}res Organiques (LCPO, CNRS UMR 5629) is also acknowledged. The research contract of C. Vilela is funded by national funds (OE), through FCT – Funda{\c c}{\~a}o para a Ci{\^e}ncia e a Tecnologia , I.P., in the scope of the framework contract foreseen in the numbers 4, 5 and 6 of article 23, of the Decree-Law 57/2016, of August 29, changed by Law 57/2017, of July 19. FCT is also acknowledged for the research contract under Stimulus of Scientific Employment 2017 to C.S.R. Freire (CEECIND/00464/2017). The NMR spectrometers are part of the National NMR Network (PTNMR) and are partially supported by Infrastructure Project N° 022161 (co-financed by FEDER through COMPETE 2020, POCI and PORL and FCT through PIDDAC). Funding Information: This work was developed within the scope of project CICECO-Aveiro Institute of Materials (FCT Ref. UID/CTM/50011/2019), financed by national funds through the FCT/MEC. G. Chantereau thanks the European Joint Doctorate in Functional Materials Research EJD FunMat (Grant agreement ID: 641640) for the PhD fellowship. Laboratoire de Chimie des Polym?res Organiques (LCPO, CNRS UMR 5629) is also acknowledged. The research contract of C. Vilela is funded by national funds (OE), through FCT ? Funda??o para a Ci?ncia e a Tecnologia, I.P. in the scope of the framework contract foreseen in the numbers 4, 5 and 6 of article 23, of the Decree-Law 57/2016, of August 29, changed by Law 57/2017, of July 19. FCT is also acknowledged for the research contract under Stimulus of Scientific Employment 2017 to C.S.R. Freire (CEECIND/00464/2017). The NMR spectrometers are part of the National NMR Network (PTNMR) and are partially supported by Infrastructure Project N? 022161 (co-financed by FEDER through COMPETE 2020, POCI and PORL and FCT through PIDDAC). Publisher Copyright: {\textcopyright} 2020 Elsevier B.V.",

year = "2020",

month = mar,

day = "15",

doi = "10.1016/j.molliq.2020.112547",

language = "English",

volume = "302",

journal = "Journal of Molecular Liquids",

issn = "0167-7322",

publisher = "Elsevier",

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TY - JOUR

T1 - Bacterial nanocellulose membranes loaded with vitamin B-based ionic liquids for dermal care applications

AU - Chantereau, G.

AU - Sharma, M.

AU - Abednejad, A.

AU - Vilela, C.

AU - Costa, E. M.

AU - Veiga, M.

AU - Antunes, F.

AU - Pintado, M. M.

AU - Sèbe, G.

AU - Coma, V.

AU - Freire, M. G.

AU - Freire, C. S. R.

AU - Silvestre, A. J. D.

N1 - Funding Information: This work was developed within the scope of project CICECO-Aveiro Institute of Materials (FCT Ref. UID/CTM/50011/2019 ), financed by national funds through the FCT / MEC . G. Chantereau thanks the European Joint Doctorate in Functional Materials Research EJD FunMat (Grant agreement ID: 641640) for the PhD fellowship. Laboratoire de Chimie des Polymères Organiques (LCPO, CNRS UMR 5629) is also acknowledged. The research contract of C. Vilela is funded by national funds (OE), through FCT – Fundação para a Ciência e a Tecnologia , I.P., in the scope of the framework contract foreseen in the numbers 4, 5 and 6 of article 23, of the Decree-Law 57/2016, of August 29, changed by Law 57/2017, of July 19. FCT is also acknowledged for the research contract under Stimulus of Scientific Employment 2017 to C.S.R. Freire (CEECIND/00464/2017). The NMR spectrometers are part of the National NMR Network (PTNMR) and are partially supported by Infrastructure Project N° 022161 (co-financed by FEDER through COMPETE 2020, POCI and PORL and FCT through PIDDAC). Funding Information: This work was developed within the scope of project CICECO-Aveiro Institute of Materials (FCT Ref. UID/CTM/50011/2019), financed by national funds through the FCT/MEC. G. Chantereau thanks the European Joint Doctorate in Functional Materials Research EJD FunMat (Grant agreement ID: 641640) for the PhD fellowship. Laboratoire de Chimie des Polym?res Organiques (LCPO, CNRS UMR 5629) is also acknowledged. The research contract of C. Vilela is funded by national funds (OE), through FCT ? Funda??o para a Ci?ncia e a Tecnologia, I.P. in the scope of the framework contract foreseen in the numbers 4, 5 and 6 of article 23, of the Decree-Law 57/2016, of August 29, changed by Law 57/2017, of July 19. FCT is also acknowledged for the research contract under Stimulus of Scientific Employment 2017 to C.S.R. Freire (CEECIND/00464/2017). The NMR spectrometers are part of the National NMR Network (PTNMR) and are partially supported by Infrastructure Project N? 022161 (co-financed by FEDER through COMPETE 2020, POCI and PORL and FCT through PIDDAC). Publisher Copyright: © 2020 Elsevier B.V.

PY - 2020/3/15

Y1 - 2020/3/15

N2 - The development of innovative bio-based skin care products has received an increased attention in the latter years. In the present work, the synthesis of original active principle ingredients based on ionic liquids (ILs) with cholinium cation and vitamins B anions, followed by their incorporation in bacterial nanocellulose (BC) membranes for topical applications, is reported. Three ILs, namely cholinium nicotinate [Ch][B3], cholinium pantothenate [Ch][B5] and cholinium pyridoxylate [Ch][B6], were synthesized through a metathesis reaction and their structure characterized in detail. Thermal analysis confirmed their denomination as ILs and their high thermal resistance. The solubility of these ILs was higher than their vitamin precursors, especially in the case of [Ch][B3] whose solubility increased 30.6-fold enhancing the bioavailability of this vitamin. The incorporation of ILs in BC led to translucent and homogeneous membranes stable up to 190 °C. ILs acted as plasticizers reducing BC brittleness that facilitated their application on irregular skin regions. Moreover, the re-hydration ability of BC-ILs membranes was improved 2.9 to 4.8-fold in comparison to BC, ensuring adequate hydration for ILs release, while the release of ILs in buffer solutions was more complete and faster than the release of vitamins. Finally, BC-ILs were proven not cytotoxic to skin epithelial cells and thus are suitable materials for skin care applications.

AB - The development of innovative bio-based skin care products has received an increased attention in the latter years. In the present work, the synthesis of original active principle ingredients based on ionic liquids (ILs) with cholinium cation and vitamins B anions, followed by their incorporation in bacterial nanocellulose (BC) membranes for topical applications, is reported. Three ILs, namely cholinium nicotinate [Ch][B3], cholinium pantothenate [Ch][B5] and cholinium pyridoxylate [Ch][B6], were synthesized through a metathesis reaction and their structure characterized in detail. Thermal analysis confirmed their denomination as ILs and their high thermal resistance. The solubility of these ILs was higher than their vitamin precursors, especially in the case of [Ch][B3] whose solubility increased 30.6-fold enhancing the bioavailability of this vitamin. The incorporation of ILs in BC led to translucent and homogeneous membranes stable up to 190 °C. ILs acted as plasticizers reducing BC brittleness that facilitated their application on irregular skin regions. Moreover, the re-hydration ability of BC-ILs membranes was improved 2.9 to 4.8-fold in comparison to BC, ensuring adequate hydration for ILs release, while the release of ILs in buffer solutions was more complete and faster than the release of vitamins. Finally, BC-ILs were proven not cytotoxic to skin epithelial cells and thus are suitable materials for skin care applications.

KW - Antioxidant activity

KW - Bacterial nanocellulose

KW - Cholinium-based ILs

KW - Ionic liquids

KW - Skin care applications

KW - Vitamin B

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U2 - 10.1016/j.molliq.2020.112547

DO - 10.1016/j.molliq.2020.112547

M3 - Article

AN - SCOPUS:85078665919

SN - 0167-7322

VL - 302

JO - Journal of Molecular Liquids

JF - Journal of Molecular Liquids

M1 - 112547

ER -

Bacterial nanocellulose membranes loaded with vitamin B-based ionic liquids for dermal care applications

Abstract

Keywords

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CBQF Multianual Funding: Centre for Biotechnology and Fine Chemistry

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Bacterial nanocellulose membranes loaded with vitamin B-based ionic liquids for dermal care applications

Abstract

Keywords

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Projects

CBQF Multianual Funding: Centre for Biotechnology and Fine Chemistry

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