TY - JOUR
T1 - Bilirubin dependence on UGT1A1 polymorphisms, hemoglobin, fasting time and body mass index
AU - Rodrigues, Carina
AU - Costa, Elísio
AU - Vieira, Emília
AU - Carvalho, João de
AU - Santos, Rosário
AU - Rocha-Pereira, Petronila
AU - Santos-Silva, Alice
AU - Bronze-Da-Rocha, Elsa
N1 - Funding Information:
This study was supported by PhD grant (SFRH/BD/42791/2007) from Fundação para a Ciência e Tecnologia (FCT) and Fundo Social Europeu (FSE) attributed to Carina Rodrigues.
PY - 2012/2
Y1 - 2012/2
N2 - In humans, bilirubin levels are influenced by different factors. This study evaluates how several nongenetic causes and the genetic UGT1A1 polymorphisms contribute for bilirubin levels, in a cohort of 146 young Caucasian females. Hematological data, bilirubin, screening of TA duplication in the UGT1A1 gene, body mass index (BMI) and body fat were determined. A questionnaire about fasting time, smoking habits, oral contraceptive therapy, caloric intake and physical activity was done. Participants were divided according to the tertiles of bilirubin. Subjects from the second and third tertile had significant rises in hemoglobin (Hb), hematocrit, mean cell Hb and mean cell Hb concentration, and a significant increased frequency for the c.-41 -40dupTA allele in homozygosity, when compared to the first tertile. Red blood cell count was significantly increased in the third tertile. Results showed that the c.-41-40dupTA allele (genetic), Hb, BMI and fasting time (nongenetic) were the main factors associated bilirubin levels.
AB - In humans, bilirubin levels are influenced by different factors. This study evaluates how several nongenetic causes and the genetic UGT1A1 polymorphisms contribute for bilirubin levels, in a cohort of 146 young Caucasian females. Hematological data, bilirubin, screening of TA duplication in the UGT1A1 gene, body mass index (BMI) and body fat were determined. A questionnaire about fasting time, smoking habits, oral contraceptive therapy, caloric intake and physical activity was done. Participants were divided according to the tertiles of bilirubin. Subjects from the second and third tertile had significant rises in hemoglobin (Hb), hematocrit, mean cell Hb and mean cell Hb concentration, and a significant increased frequency for the c.-41 -40dupTA allele in homozygosity, when compared to the first tertile. Red blood cell count was significantly increased in the third tertile. Results showed that the c.-41-40dupTA allele (genetic), Hb, BMI and fasting time (nongenetic) were the main factors associated bilirubin levels.
KW - Bilirubin levels
KW - Genetic and nongenetic factors
KW - Gilberts syndrome
KW - Hemoglobin
KW - UGT1A1
UR - http://www.scopus.com/inward/record.url?scp=84856645852&partnerID=8YFLogxK
U2 - 10.1097/MAJ.0b013e318223460f
DO - 10.1097/MAJ.0b013e318223460f
M3 - Article
C2 - 21760472
AN - SCOPUS:84856645852
SN - 0002-9629
VL - 343
SP - 114
EP - 118
JO - American Journal of the Medical Sciences
JF - American Journal of the Medical Sciences
IS - 2
ER -
