Bioactive peptides - are there more antihypertensive mechanisms beyond ace inhibition?

Cláudia Marques, Maria Manuela Amorim, Joana Odila Pereira, Manuela Estevez Pintado, Daniel Moura, Conceição Calhau, Hélder Pinheiro*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

32 Citations (Scopus)


Diet has a high relevance in health. Hypertension is a major risk factor for cardiovascular diseases and has an important impact on public health, and consequently on countries economy. Scientific research gathered strong evidence about the role of several dietary factors either in etiology or in treatment/prevention of these diseases. Peptides from different food matrices have been studied, and indicated as compounds with particular interest in the context of hypertension. The classical approach involves the identification of peptides with an in vitro ACE inhibitory activity and the assumption that the observed in vivo effects are due to this enzyme blockade. However, in some cases the potency of ACE blockade does not correlate with the antihypertensive activity in vivo. This paper reviews the current literature that identifies mechanisms of action, other than ACE inhibition, that might explain antihypertensive effects of biologically active peptides from different food sources.

Original languageEnglish
Pages (from-to)4706-4713
Number of pages8
JournalCurrent Pharmaceutical Design
Issue number30
Publication statusPublished - 2012


  • ACE
  • Bioactive peptides
  • Biopeptides
  • Hypertension
  • Mechanisms of action
  • Renin-angiotensin system


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