TY - JOUR
T1 - Biocompatibility of wollastonite-poly(N-butyl-2-cyanoacrylate) composites
AU - Sena, Lídia Ágata de
AU - Almeida, Marcelo Sanmartin de
AU - Fernandes, Gustavo V. de Oliveira
AU - Guerra Bretaña, Rosa M.
AU - Castro-Silva, Igor Iuco
AU - Granjeiro, José Mauro
AU - Achete, Carlos Alberto
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2014/8
Y1 - 2014/8
N2 - Wollastonite-poly(n-butyl-2-cyanoacrylate) composite (W-BCA) has been proposed to immobilize anatomically bone fragments in order to achieve an optimal healing process. The present study evaluated the in vitro and in vivo behavior of three types of fillers: powdered natural wollastonite (Wn), synthetic pseudowollastonite powder (Ws), and synthetic pseudowollastonite powder coated with 5% acetyl tributyl citrate (Wst). The Wst-BCA composite underwent a higher degradability in the real-time degradation test and a superior cytotoxic effect; whereas the Wn-BCA composite showed a higher degradability in the accelerated test with no cytotoxicity. The formation of an extracellular collagenous matrix deposit on its surface and the most favorable new bone formation on Wn-BCA indicate its potential for bone adhesive use in unstable orthopedic traumas.
AB - Wollastonite-poly(n-butyl-2-cyanoacrylate) composite (W-BCA) has been proposed to immobilize anatomically bone fragments in order to achieve an optimal healing process. The present study evaluated the in vitro and in vivo behavior of three types of fillers: powdered natural wollastonite (Wn), synthetic pseudowollastonite powder (Ws), and synthetic pseudowollastonite powder coated with 5% acetyl tributyl citrate (Wst). The Wst-BCA composite underwent a higher degradability in the real-time degradation test and a superior cytotoxic effect; whereas the Wn-BCA composite showed a higher degradability in the accelerated test with no cytotoxicity. The formation of an extracellular collagenous matrix deposit on its surface and the most favorable new bone formation on Wn-BCA indicate its potential for bone adhesive use in unstable orthopedic traumas.
KW - Butylcyanoacrylate
KW - Composite
KW - Cytotoxicity
KW - Implantation
KW - Wollastonite
UR - http://www.scopus.com/inward/record.url?scp=84904044359&partnerID=8YFLogxK
U2 - 10.1002/jbm.b.33093
DO - 10.1002/jbm.b.33093
M3 - Article
C2 - 24554625
AN - SCOPUS:84904044359
SN - 1552-4973
VL - 102
SP - 1121
EP - 1129
JO - Journal of Biomedical Materials Research - Part B Applied Biomaterials
JF - Journal of Biomedical Materials Research - Part B Applied Biomaterials
IS - 6
ER -