Biomaterials in meniscus tissue engineering

João B. Costa*, Joaquim Miguel Oliveira, Rui Luís Reis

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

7 Citations (Scopus)

Abstract

Meniscus is a complex tissue that plays important roles on the knee performance and homeostasis. The meniscus tissue is very susceptible to injury and despite the great advances in meniscus regeneration area, none of the current strategies for the treatment of meniscus lesions are completely effective. To overcome such great challenge, tissue engineering-based strategies have been attempted. One of the main targets in this research area is to find out a biomaterial or formulations that are able to mimic as much as possible the meniscus native extracellular matrix. In the last few years the characteristics and behaviors of different biomaterials were explored and several processing routes attempted to obtain an adequate architecture for proper cells adhesion, ingrowths, proliferation and differentiation. Herein, a panoply of biomaterials that have been used in meniscus tissue engineering strategies are overviewed.
Original languageEnglish
Title of host publicationRegenerative strategies for the treatment of knee joint disabilities
EditorsJoaquim Miguel Oliveira, Rui Luís Reis
PublisherSpringer
Pages249-270
Number of pages22
ISBN (Electronic)9783319447858
ISBN (Print)9783319447834, 9783319831350
DOIs
Publication statusPublished - 2017
Externally publishedYes

Publication series

NameStudies in Mechanobiology, Tissue Engineering and Biomaterials
Volume21
ISSN (Print)1868-2006
ISSN (Electronic)1868-2014

Keywords

  • Bacterial cellulose
  • PLGA Scaffold
  • Partial meniscectomy
  • Silk fibroin
  • Ultrahigh molecular weight polyethylene

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