Biomimetic coatings incorporating bisphosphonates aiming to inhibit bone resorption

A. L. Oliveira*, M. I. Santos, O. P. Coutinho, R. L. Reis

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

The effects of the biomimetic coatings incorporating bisphosphonates (BP) to inhibit bone resorption were investigated. The material used was a biodegradable blend of corn starch with ethylene vinyl alcohol that was injected moulded into the shape of disks. Aliquots of 50 μl of solution of the BP were added to the coatings followed by drying at 60°C. The cells were found to adhere and proliferate on both the non-BP and BP containing coatings. The results show that BP was successfully incorporated in the structure of a biomimetic apatite layer formed by a sodium silicate process, without compromising osteoblastic activity.

Original languageEnglish
Title of host publicationTransactions - 7th World Biomaterials Congress
Pages325-325
Number of pages1
Publication statusPublished - 2004
Externally publishedYes
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: 17 May 200421 May 2004

Publication series

NameTransactions - 7th World Biomaterials Congress

Conference

ConferenceTransactions - 7th World Biomaterials Congress
Country/TerritoryAustralia
CitySydney
Period17/05/0421/05/04

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