Bone involvement in sickle cell disease

António Almeida*, Irene Roberts

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

273 Citations (Scopus)


Bone involvement is the commonest clinical manifestation of sickle cell disease both in the acute setting such as painful vaso-occlusive crises, and as a source of chronic, progressive disability such as avascular necrosis. Management of these problems is often difficult because of the diagnostic imprecision of most laboratory and imaging investigations and because of the lack of evidence for most surgical procedures in sickle cell disease. This review first discusses the acute problems related to bone involvement in sickle cell disease, with particular reference to ndifferentiating infection from infarction, and then describes the long-term effects of sickle cell disease on bone mineral density, growth, and chronic bone and joint damage.
Original languageEnglish
Pages (from-to)482-490
Number of pages9
JournalBritish Journal of Haematology
Issue number4
Publication statusPublished - May 2005
Externally publishedYes


  • Bone
  • Osteomyelitis
  • Osteonecrosis
  • Sickle cell disease
  • Vaso-occlusion


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