Canine periodontitis: the dog as an important model for periodontal studies

Carlos Albuquerque*, Francisco Morinha, João Requicha, Teresa Martins, Isabel Dias, Henrique Guedes-Pinto, Estela Bastos, Carlos Viegas

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    75 Citations (Scopus)

    Abstract

    Periodontal disease (PD) refers to a group of inflammatory diseases caused by bacterial plaque in the periodontium and ranges from an early stage (gingivitis) to an advanced stage (periodontitis). It is a multifactorial disease that results from the interaction of the host defence mechanisms with the plaque microorganisms. Early detection, diagnosis and treatment are essential in the control of this disease. PD has an enormous impact on human and veterinary medicine due to its high prevalence. The most common animal PD models use dogs and non-human primates, although other animals (rats, mice, hamsters, rabbits, miniature pigs, ferrets, and sheep) have also been employed. Dog models have contributed significantly to the current understanding of periodontology. The most important clinical aspects of canine PD are considered in this review and the various animal models are examined with an emphasis on the role of the dog as the most useful approach for understanding human PD and in the development of new therapeutic and preventive measures.
    Original languageEnglish
    Pages (from-to)299-305
    Number of pages7
    JournalVeterinary Journal
    Volume191
    Issue number3
    DOIs
    Publication statusPublished - Mar 2012

    Keywords

    • Animal models
    • Dental
    • Dog
    • Genetics
    • Periodontal disease

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