@article{41ddc0b5f65f41799e2e92c58b13f018,
title = "Cationic pyrrolidine/pyrroline-substituted porphyrins as efficient photosensitizers against e. Coli",
abstract = "New porphyrin–pyrrolidine/pyrroline conjugates were prepared by revisiting 1,3-dipolar cycloaddition reactions between a porphyrinic azomethine ylide and a series of dipolarophiles. Cationic conjugates obtained by alkylation of the pyrrolidine/pyrroline cycloadducts showed ability to generate singlet oxygen and to produce iodine in presence of KI when irradiated with visible light. Some of the cationic derivatives showed photobactericidal properties towards a Gram-negative bioluminescent E. coli. In all cases, these features were significantly improved using KI as coadjutant, allowing, under the tested conditions, the photoinactivation of the bacterium until the detection limit of the method with a drastic reduction of the required photosensitizer concentration and irradiation time. The obtained results showed a high correlation between the ability of the cationic porphyrin derivative to produce singlet oxygen and iodine and its E. coli photoinactivation profile.",
keywords = "Cycloaddition, Dipolarophile, E. coli, Photodynamic inactivation, Photosensitizer, Porphyrin, Potassium iodide",
author = "Ladeira, {Bruno M.F.} and Dias, {Cristina J.} and Gomes, {Ana T.P.C.} and Tom{\'e}, {Augusto C.} and Neves, {Maria G.P.M.S.} and Moura, {Nuno M.M.} and Adelaide Almeida and Faustino, {M. Amparo F.}",
note = "Funding Information: Funding: Thanks are due to the University of Aveiro and FCT/MCT for the financial support for the LAQV-REQUIMTE (UIDB/50006/2020) and CESAM ((UID/AMB/50017/2019 and UIDB/50017/2020 + UIDP/50017/2020) research units and to the FCT project PREVINE (FCT-PTDC/ASP-PES/29576/2017), through national founds and, where applicable, co-financed by the FEDER–Operational Thematic Program for Competitiveness and Internationalization−COMPETE 2020, within the PT2020 Partnership Agreement, and to the Portuguese NMR Network. Cristina J Dias also thanks FCT for her research grant (BI/UI51/8448/2018). NMM Moura thanks his research contract (CDL-CTTRI-88-89-97-ARH/2018) which is funded by national funds (OE), through FCT—Funda{\c c}{\~a}o para a Ci{\^e}ncia e a Tecnologia, I.P., in the scope of the framework contract foreseen in numbers 4, 5 and 6 of the article 23, of the Law Decree 57/2016, of August 29, changed by Law 57/2017, of July 19. Publisher Copyright: {\textcopyright} 2021 by the authors. Li-censee MDPI, Basel, Switzerland.",
year = "2021",
month = jan,
day = "1",
doi = "10.3390/molecules26020464",
language = "English",
volume = "26",
journal = "Molecules",
issn = "1420-3049",
publisher = "MDPI",
number = "2",
}