Changes in albumin-to-creatinine ratio at 12-month follow-up in patients undergoing renal denervation

Henrique Sousa , Patrícia Branco , Manuel de Sousa Almeida, Pedro de Araújo Gonçalves*, Augusta Gaspar , Hélder Alexandre Correia Dores, João Mesquita, Maria João Andrade, Nuno Neuparth , Ana Aleixo, Miguel Mendes, João Diogo Barata

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Introduction Sympathetic renal denervation (RDN) was developed as a treatment for the management of patients with resistant hypertension. This procedure may have a positive impact on hypertension-related target organ damage, particularly renal disease, but the evidence is still limited. Objective To assess the impact of RDN on the albumin-to-creatinine ratio (ACR) at 12-month follow-up. Methods and Results From a single-center prospective registry including 65 patients with resistant hypertension undergoing renal denervation, 31 patients with complete baseline and 12-month follow-up blood pressure (BP) measurements (both office and 24-h ambulatory blood pressure monitoring [ABPM]) and ACR were included in the present study. Mean age was 65±7 years, 52% were female, most (90%) had been diagnosed with hypertension for more than 10 years, 71% had type 2 diabetes and 33% had vascular disease in at least one territory. Mean estimated glomerular filtration rate was 73.6±25.1 ml/min/1.73 m 2 and 15 patients (48%) had an ACR >30 mg/g. After 12 months, 22 patients were considered BP responders (73%). ACR decreased significantly from a median of 25.8 mg/g (interquartile range [IQR] 9.0-574.0 mg/g) to 14.8 mg/g (IQR 4.5-61.0 mg/g, p=0.007). When the results were split according to systolic BP responder status on ABPM, we found a significant reduction in responders (from 25.6 mg/g [IQR 8.7-382.8 mg/g] to 15.9 mg/g [IQR 4.4-55.0 mg/g], p=0.009), and a numerical decrease in the non-responder subgroup (from 165.0 mg/g [IQR 8.8-1423.5 mg/g] to 13.6 mg/dl [IQR 5.7-1417.0 mg/g], p=0.345). Conclusions Besides significant reductions in blood pressure (both office and 24-h ABPM), renal denervation was associated with a significant reduction in ACR, a recognized marker of target organ damage.
Translated title of the contributionRácio albumina-creatinina aos 12 meses de seguimento após desnervação renal
Original languageEnglish
Pages (from-to)343-351
Number of pages9
JournalRevista Portuguesa de Cardiologia
Volume36
Issue number5
DOIs
Publication statusPublished - May 2017
Externally publishedYes

Keywords

  • Resistant hypertension
  • Renal denervation
  • Albuminuria
  • Blood pressure

Fingerprint

Dive into the research topics of 'Changes in albumin-to-creatinine ratio at 12-month follow-up in patients undergoing renal denervation'. Together they form a unique fingerprint.

Cite this