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Abstract
Carboxymethyl cellulose is the most used water-soluble cellulose with applications in industries such as food, cosmetics, and tissue engineering. However, due to a perceived lack of biological activity, carboxymethyl cellulose is mostly used as a structural element. As such, this work sought to investigate whether CMC possesses relevant biological properties that could grant it added value as a cosmeceutical ingredient in future skincare formulations. To that end, CMC samples (Mw between 471 and 322 kDa) skin cell cytotoxicity, impact upon pro-collagen I α I production, and inflammatory response were evaluated. Results showed that samples were not cytotoxic towards HaCat and HDFa up to 10 mg/mL while simultaneously promoting intracellular production of pro-collagen I α I up by 228% relative to the basal metabolism, which appeared to be related to the highest DS and Mw. Additionally, CMC samples modulated HaCat immune response as they decreased by ca. 1.4-fold IL-8 production and increased IL-6 levels by ca. five fold. Despite this increase, only two samples presented IL-6 levels similar to those of the inflammation control. Considering these results, CMC showed potential to be a more natural alternative to traditional bioactive cosmetic ingredients and, as it is capable of being a bioactive and structural ingredient, it may play a key role in future skincare formulations.
Original language | English |
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Article number | 6560 |
Pages (from-to) | 1-16 |
Number of pages | 16 |
Journal | Applied Sciences |
Volume | 12 |
Issue number | 13 |
DOIs | |
Publication status | Published - 28 Jun 2022 |
Keywords
- Carboxymethyl cellulose
- Cosmeceutical
- Immunomodulation
- Pro-collagen production
- Skin keratinocytes
- Skin normal fibroblasts
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Dive into the research topics of 'Characterization and evaluation of commercial carboxymethyl cellulose potential as an active ingredient for cosmetics'. Together they form a unique fingerprint.Projects
- 1 Finished
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ALCHEMY: Capturing High Value from Industrial Fermentation BioProducts
Pintado, M. M. (PI) & Pimentel, L. (Researcher)
1/01/18 → 30/06/23
Project: Research