Projects per year
Abstract
Carboxymethyl cellulose is the most used water-soluble cellulose with applications in industries such as food, cosmetics, and tissue engineering. However, due to a perceived lack of biological activity, carboxymethyl cellulose is mostly used as a structural element. As such, this work sought to investigate whether CMC possesses relevant biological properties that could grant it added value as a cosmeceutical ingredient in future skincare formulations. To that end, CMC samples (Mw between 471 and 322 kDa) skin cell cytotoxicity, impact upon pro-collagen I α I production, and inflammatory response were evaluated. Results showed that samples were not cytotoxic towards HaCat and HDFa up to 10 mg/mL while simultaneously promoting intracellular production of pro-collagen I α I up by 228% relative to the basal metabolism, which appeared to be related to the highest DS and Mw. Additionally, CMC samples modulated HaCat immune response as they decreased by ca. 1.4-fold IL-8 production and increased IL-6 levels by ca. five fold. Despite this increase, only two samples presented IL-6 levels similar to those of the inflammation control. Considering these results, CMC showed potential to be a more natural alternative to traditional bioactive cosmetic ingredients and, as it is capable of being a bioactive and structural ingredient, it may play a key role in future skincare formulations.
| Original language | English |
|---|---|
| Article number | 6560 |
| Pages (from-to) | 1-16 |
| Number of pages | 16 |
| Journal | Applied Sciences |
| Volume | 12 |
| Issue number | 13 |
| DOIs | |
| Publication status | Published - 28 Jun 2022 |
Keywords
- Carboxymethyl cellulose
- Cosmeceutical
- Immunomodulation
- Pro-collagen production
- Skin keratinocytes
- Skin normal fibroblasts
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CBQF Multianual Funding: Centre for Biotechnology and Fine Chemistry
Cortez, J., Pintado, M. M., Morais, A. M. M. B., Ribeiro, A. B., Ferreira, A. C., Castro, P. M. L., Villamor, A. L., Oliveira, A. L., Oliveira, A. L. S., Amaro, A. L., Paulo, A., Gomes, A. M., Marques, A., Carvalho, A. P., Monforte, A. R., Madureira, A. R., Oliveira, A. S., Ferreira, A. S., Rangel, A. O. S. S., Oliveira, C., Oliveira, C., Pereira, C. F., Santos, C. S. D., Amorim, C. L., Oliveira, C., Manaia, C., Silva, C. L. M., Monteiro, C. M., Machado, D., Campos, D., Oliveira, D., Valente, D., Cardoso, E., Costa, E. M. A. D., Pinto, E., Alexandre, E., Carsanba, E., Coscueta, E., Raposo, M. F. D. J., Tavaria, F., Voss, G. B., Moreira, H., Campos, I., Tomada, I., Moreira, I. S., Vaz-Moreira, I., Fundo, J. F., Barbosa, J. I. B., Pereira, J. O., Durão, J. R. D. O., Costa, J. R., Fernandes, J. C., Ferreira, J., Silva, J. A., Couto, J. A., Oliveira, L., Pimentel, L., Rodríguez-Alcalá, L. M., Hogg, C., Poças, M. D. F., Miller, F. A., Brassesco, M. E., Mota, I., Ramos, I. N., Vasconcelos, I., Monteiro, M. J., Amorim, M., Roriz, M., Silva, M., Correia, M., Silva, M. N. D., Alves, M., Vasconcelos, M., Ramos, O. L., Costa, P., Gibbs, P., Teixeira, P., Ramos, P., Rodrigues, P. M., Carvalho, P., Mesquita, R., Barros, R., Morais, R. M. S. C., Magalhães, R. M. B. D. S., Borges, S. C. F., Correia, S., Silva, S. B. D., Silva, S., Moreira, S. A. M., Pedrosa, S., Pereira, S., Vidigal, S., Pedro, T., Ribeiro, T., Deuchande, T., Brandão, T. R. S., Resende, T., Hogg, T., Ferreira, V., Viseras, A. D., Soares, A. M. S., Oliveira, A. S., Uribe, B., Pais-Vieira, C., Ferreira, C., Sousa, C. C. S., Kumla, D., Carsanba, E., Lopes, G. L. L., Ribeiro, I. M. M. V. P., Cruz, I. B. D., Barbosa, J. C., Oliveira, L., Mendes, M. A. R., Boas, A. V., Cassoni, A. C., Lopes, A., Pintado, A. I. E., Sousa, A. P., Faustino, M., Salsinha, A. S., Couto, A. T., Macieira, A., Horta, B. M., Maciel, C., Rodrigues, C. M., Bernardes, B. G., Silva, B., Costa, C., Costa, C. M., Serafim, C., Santos, D., Antunes, F., Vieira, E., Ferreira, H., Moreira, I. A., Vieira, I. R. D. F., Rocha, J., Henggeler , J., Miranda, J., Oliveira, M., Lopes, M. T. B. V., Silva, N., Carvalho, N., Costa, P., Nova, P., Sousa, P., Silva, P., Gómez-García, R., Freixo, R., Marçal, S., Cunha, S. A. S., Sousa, S., Pereira, S. A., Ghalamara, S., Vilela, T., Lopes, A., Lopes, A. I., Linhares, A. L. S., Vilas-Boas, A. M., Teixeira, A. M. R., Mendes, A. R., Oliveira, A. S., Sousa, A. S. D. S., Sousa, A. S. D. S., Martins, A. P., Veiga, A., Bernardes, B. G., Silva, B., Fernandes, A., Miranda, C., Dias, C. L. A., Neto, C. C., Castro, C. M. O., Oliveira, D. F., Rodrigues, D., Magalhães, D. D. S., Almeida, D., Castro, D., Costa, E. C. L. D., Darú, F. A., Bastos, F., Teixeira, F. D. S., Ferreira, F., Fortunato, G., Araújo-Rodrigues, H., Osorio Pérez, J. R., Silveira, J. F., Silva, J. A., Soares, J. C., Carvalho, L. C., Castro, L. M. G., Machado, M., Carvalho, M. J., Nazareth, M., Veiga, M., Coelho, M., Carvalho, M. I. P. D., Mendes, M., Ramos, M. A. M., Silva, T., Resende, T., Fontes, A. L., Neves, D. I. S. C. D., Cachetas, D. M., Silva, G. A. D. R. & Morais, R. M. S. C.
1/01/20 → 31/12/23
Project: Research
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ALCHEMY: Capturing High Value from Industrial Fermentation BioProducts
1/01/18 → 30/06/23
Project: Research