Characterization of cytomegalovirus and epstein-barr virus infection in cervical lesions in Portugal

Joana Marinho-Dias, Joana Ribeiro, Paula Monteiro, Joana Loureiro, Inês Baldaque, Rui Medeiros, Hugo Sousa*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Infection by high-risk types of human papillomavirus (HPV) is considered necessary but not sufficient for the development of cervical cancer. Previous studies suggested that cytomegalovirus (CMV) and Epstein-barr virus (EBV) could be co-factors of HPV-associated carcinogenesis. The aim of this study was to characterize the prevalence of CMV and EBV and evaluate its association with the development cervical lesions in Portugal. The prevalence of CMV and EBV infections was determined by real-time PCR in 89 cervical samples from women with different histological lesions, who attended the Portuguese Institute of Oncology of Porto. This study revealed an overall prevalence of 4.5% for CMV and 10.1% for EBV. Age-stratified analysis revealed that CMV infection was present in individuals <30 and >60 years old, while EBV infection was present in all age groups. CMV was detected in 9.5% of low-grade lesions and in 22.2% of in situ/invasive carcinomas, while EBV infection was found in all different types of lesions. In addition, data revealed that CMV infection was associated with an increased risk of in situ/invasive carcinoma development (OR = 1.28; P = 0.035). The study reveals a low prevalence for both viruses; nevertheless, these results are important for knowledge on the shedding of EBV and CMV in cervical samples.
Original languageEnglish
Pages (from-to)1409-1413
Number of pages5
JournalJournal of Medical Virology
Issue number8
Publication statusPublished - Aug 2013


  • Cervical cancer
  • Cervix
  • Cytomegalovirus (CMV)
  • Epstein-Barr Virus (EBV)


Dive into the research topics of 'Characterization of cytomegalovirus and epstein-barr virus infection in cervical lesions in Portugal'. Together they form a unique fingerprint.

Cite this