TY - UNPB
T1 - Chikungunya virus outbreak in the Amazon region: replacement of the Asian genotype by an ECSA lineage
AU - Naveca, Felipe Gomes
AU - Claro, Ingra
AU - Giovanetti, Marta
AU - Jesus, Jaqueline Goes de
AU - Xavier, Joilson
AU - Iani, Felipe Campos de Melo
AU - Nascimento, Valdinete Alves do
AU - Souza, Victor Costa de
AU - Silveira, Paola Paz
AU - Lourenço, José
AU - Santillana, Mauricio
AU - Kraemer, Moritz U. G.
AU - Quick, Josh
AU - Hill, Sarah C.
AU - Theze, Julien
AU - Carvalho, Rodrigo Dias de Oliveira
AU - Azevedo, Vasco
AU - Sales, Flavia Cristina da Silva
AU - Nunes, Márcio Roberto Teixeira
AU - Lemos, Poliana da Silva
AU - Candido, Darlan da Silva
AU - Pereira, Glauco de Carvalho
AU - Oliveira, Marluce Aparecida Assunção
AU - Meneses, Catia Alexandra Ribeiro
AU - Maito, Rodrigo Melo
AU - Cunha, Claudeth Rocha Santa Brígida
AU - Campos, Daniela Palha de Sousa
AU - Castilho, Marcia da Costa
AU - Siqueira, Thalita Caroline da Silva
AU - Terra, Tiza Matos
AU - Albuquerque, Carlos F. Campelo de
AU - Cruz, Laura Nogueira da
AU - Abreu, André Luis de
AU - Martins, Divino Valerio
AU - Simoes, Daniele Silva de Moraes Vanlume
AU - Aguiar, Renato Santana
AU - Luz, Sergio Luiz Bessa
AU - Loman, Nicholas
AU - Pybus, Oliver G.
AU - Sabino, Ester Cerdeira
AU - Okumoto, Osnei
AU - Alcantara, Luiz Carlos Junior
AU - Faria, Nuno Rodrigues
PY - 2018/12/10
Y1 - 2018/12/10
N2 - Until the end of 2017, Brazil notified the highest number of infections caused by chikungunya virus (CHIKV) in the Americas. We investigated a large CHIKV outbreak in Boa vista municipality in the Brazilian Amazon region. Rapid portable genome sequencing of 20 novel isolates and subsequent genetic analysis revealed that ECSA lineage was introduced from northeastern Brazil to Roraima around July 2016. Epidemiological analyses suggest a basic reproductive number of R0 of 1.66, which suggests that approximately 39% of Roraima’s population was infected with CHIKV-ECSA. Given the dominance of the CHIKV-Asian genotype in the Americas, our data highlights the rapid spread of a less understood and poorly characterized CHIKV-ECSA genotype in Brazil. Investigations on potential associations between public health impact of CHIKV and genetic diversity of circulating strains are warranted to better evaluate its impact in Brazil and beyond.
AB - Until the end of 2017, Brazil notified the highest number of infections caused by chikungunya virus (CHIKV) in the Americas. We investigated a large CHIKV outbreak in Boa vista municipality in the Brazilian Amazon region. Rapid portable genome sequencing of 20 novel isolates and subsequent genetic analysis revealed that ECSA lineage was introduced from northeastern Brazil to Roraima around July 2016. Epidemiological analyses suggest a basic reproductive number of R0 of 1.66, which suggests that approximately 39% of Roraima’s population was infected with CHIKV-ECSA. Given the dominance of the CHIKV-Asian genotype in the Americas, our data highlights the rapid spread of a less understood and poorly characterized CHIKV-ECSA genotype in Brazil. Investigations on potential associations between public health impact of CHIKV and genetic diversity of circulating strains are warranted to better evaluate its impact in Brazil and beyond.
U2 - 10.1101/492595
DO - 10.1101/492595
M3 - Preprint
BT - Chikungunya virus outbreak in the Amazon region: replacement of the Asian genotype by an ECSA lineage
ER -
