Chitosan as an effective inhibitor of multidrug resistant Acinetobacter baumannii

E. M. Costa, S. Silva, S. Vicente, M. Veiga, F. Tavaria, M. M. Pintado*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Over the last two decades worldwide levels of antibiotic resistance have risen leading to the appearance of multidrug resistant microorganisms. Acinetobacter baumannii is a known skin pathogen which has emerged as a major cause of nosocomial outbreaks due to its capacity to colonize indwelling medical devices and natural antibiotic resistance. With chitosan being an effective antimicrobial agent against antibiotic resistant microorganisms, the aim of this work was to access its potential as an alternative to traditional antimicrobials in the management of A. baumannii growth. What the results showed was that both chitosan MW's tested were active upon A. baumannii's planktonic and sessile growth. For planktonic growth MICs and MBCs were obtained at relatively low concentrations (0.5–2 mg/mL) while for sessile growth chitosan proved to be an effective inhibitor of A. baumannii's adhesion and biofilm formation. Considering these results chitosan shows a high potential for control of A. baumannii infections.
Original languageEnglish
Pages (from-to)347-351
Number of pages5
JournalCarbohydrate Polymers
Volume178
DOIs
Publication statusPublished - 15 Dec 2017

Keywords

  • Acinetobacter baumannii
  • Antibiofilm
  • Antimicrobial
  • Chitosan
  • Clinical isolate
  • Multidrug-resistance

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