Chronic ingestion of high-fat diet and energy restriction modulates expression of VEGF and VEGFR2 in aged rat myocardium

D. Fernandes; I. Tomada; H. Almeida; D. Neves

doi:10.1017/S143192761201269X

Chronic ingestion of high-fat diet and energy restriction modulates expression of VEGF and VEGFR2 in aged rat myocardium

D. Fernandes, I. Tomada, H. Almeida, D. Neves

Research output: Contribution to journal › Article › peer-review

Abstract

Cardiovascular diseases (CVD) constitute a leading cause of death in the aged population. Regular intake of hyperlipidic diet and obesity can induce endothelial dysfunction that precedes the onset of atherosclerosis and CVD. High-fat diet regular consumption leads to structural modifications in heart tissue, and changes in the expression of angiogenic factors and their specific receptors. Hence, we aimed to characterize the expression pattern of vascular endothelial growth factor (VEGF) and its membrane receptor VEGFR 2 in young and aged rat hearts under high-fat diet and energy restriction.

Original language	English
Pages (from-to)	7-8
Number of pages	2
Journal	Microscopy and Microanalysis
Volume	18
Issue number	SUPPL.5
DOIs	https://doi.org/10.1017/S143192761201269X
Publication status	Published - Oct 2012
Externally published	Yes

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10.1017/S143192761201269X

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abstract = "Cardiovascular diseases (CVD) constitute a leading cause of death in the aged population. Regular intake of hyperlipidic diet and obesity can induce endothelial dysfunction that precedes the onset of atherosclerosis and CVD. High-fat diet regular consumption leads to structural modifications in heart tissue, and changes in the expression of angiogenic factors and their specific receptors. Hence, we aimed to characterize the expression pattern of vascular endothelial growth factor (VEGF) and its membrane receptor VEGFR 2 in young and aged rat hearts under high-fat diet and energy restriction.",

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AU - Fernandes, D.

AU - Tomada, I.

AU - Almeida, H.

AU - Neves, D.

PY - 2012/10

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AB - Cardiovascular diseases (CVD) constitute a leading cause of death in the aged population. Regular intake of hyperlipidic diet and obesity can induce endothelial dysfunction that precedes the onset of atherosclerosis and CVD. High-fat diet regular consumption leads to structural modifications in heart tissue, and changes in the expression of angiogenic factors and their specific receptors. Hence, we aimed to characterize the expression pattern of vascular endothelial growth factor (VEGF) and its membrane receptor VEGFR 2 in young and aged rat hearts under high-fat diet and energy restriction.

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U2 - 10.1017/S143192761201269X

DO - 10.1017/S143192761201269X

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JO - Microscopy and Microanalysis

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IS - SUPPL.5

ER -

Chronic ingestion of high-fat diet and energy restriction modulates expression of VEGF and VEGFR2 in aged rat myocardium

Abstract

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