Clinical analysis: enzymes in physiological samples

Lígia L. Pimentel; Luís M. Rodríguez-Alcalá; Ana M. Gomes; Ana C. Freitas

doi:10.1016/B978-0-12-409547-2.14270-2

Clinical analysis: enzymes in physiological samples

Lígia L. Pimentel^*, Luís M. Rodríguez-Alcalá, Ana M. Gomes, Ana C. Freitas

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Enzymes are used as biomarkers of specific cellular damage of some organs. This article attempts to address the most important enzymes associated with heart diseases, liver, pancreas, and neuromuscular damage and also the cellular signaling of inflammation of adipose tissue. Some of the enzymes acting as diagnostic biomarkers are lactate dehydrogenase, creatine kinase, aspartate aminotransferase, aldolase, carbonic anhydrase, and alpha-amylase while leptin and asprosin are key markers for adipose tissue inflammation. Evolution and limitations of using enzymes as serum biomarkers are discussed. The methods usually used to determine enzymes as biomarkers as well as their reference values are also described.

Original language	English
Title of host publication	Encyclopedia of analytical science
Publisher	Elsevier
Pages	138-147
Number of pages	10
ISBN (Electronic)	9780081019832
ISBN (Print)	9780081019849
DOIs	https://doi.org/10.1016/B978-0-12-409547-2.14270-2
Publication status	Published - 1 Jan 2019

Keywords

Adipokines
Adipose tissue
Alanine aminotransferase
Alkaline phosphatase
Alpha-amylase
Aspartate aminotransferase
Asprosin
Carbonic anhydrase
Cardiac function
Creatine kinase
Diagnostic/prognostic biomarkers
Enzymes
Gamma glutamyl transferase
Lactate dehydrogenase
Leptin
Liver tests
Neuromuscular biomarkers
Pancreatitis

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10.1016/B978-0-12-409547-2.14270-2

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title = "Clinical analysis: enzymes in physiological samples",

abstract = "Enzymes are used as biomarkers of specific cellular damage of some organs. This article attempts to address the most important enzymes associated with heart diseases, liver, pancreas, and neuromuscular damage and also the cellular signaling of inflammation of adipose tissue. Some of the enzymes acting as diagnostic biomarkers are lactate dehydrogenase, creatine kinase, aspartate aminotransferase, aldolase, carbonic anhydrase, and alpha-amylase while leptin and asprosin are key markers for adipose tissue inflammation. Evolution and limitations of using enzymes as serum biomarkers are discussed. The methods usually used to determine enzymes as biomarkers as well as their reference values are also described.",

keywords = "Adipokines, Adipose tissue, Alanine aminotransferase, Alkaline phosphatase, Alpha-amylase, Aspartate aminotransferase, Asprosin, Carbonic anhydrase, Cardiac function, Creatine kinase, Diagnostic/prognostic biomarkers, Enzymes, Gamma glutamyl transferase, Lactate dehydrogenase, Leptin, Liver tests, Neuromuscular biomarkers, Pancreatitis",

author = "Pimentel, {L{\'i}gia L.} and Rodr{\'i}guez-Alcal{\'a}, {Lu{\'i}s M.} and Gomes, {Ana M.} and Freitas, {Ana C.}",

note = "Funding Information: Supported by a grant from Fisons Corp, Boston, Massachusetts. Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd.",

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doi = "10.1016/B978-0-12-409547-2.14270-2",

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T2 - enzymes in physiological samples

AU - Pimentel, Lígia L.

AU - Rodríguez-Alcalá, Luís M.

AU - Gomes, Ana M.

AU - Freitas, Ana C.

PY - 2019/1/1

Y1 - 2019/1/1

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AB - Enzymes are used as biomarkers of specific cellular damage of some organs. This article attempts to address the most important enzymes associated with heart diseases, liver, pancreas, and neuromuscular damage and also the cellular signaling of inflammation of adipose tissue. Some of the enzymes acting as diagnostic biomarkers are lactate dehydrogenase, creatine kinase, aspartate aminotransferase, aldolase, carbonic anhydrase, and alpha-amylase while leptin and asprosin are key markers for adipose tissue inflammation. Evolution and limitations of using enzymes as serum biomarkers are discussed. The methods usually used to determine enzymes as biomarkers as well as their reference values are also described.

KW - Adipokines

KW - Adipose tissue

KW - Alanine aminotransferase

KW - Alkaline phosphatase

KW - Alpha-amylase

KW - Aspartate aminotransferase

KW - Asprosin

KW - Carbonic anhydrase

KW - Cardiac function

KW - Creatine kinase

KW - Diagnostic/prognostic biomarkers

KW - Enzymes

KW - Gamma glutamyl transferase

KW - Lactate dehydrogenase

KW - Leptin

KW - Liver tests

KW - Neuromuscular biomarkers

KW - Pancreatitis

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AN - SCOPUS:85079265030

SN - 9780081019849

SP - 138

EP - 147

BT - Encyclopedia of analytical science

PB - Elsevier

ER -

Clinical analysis: enzymes in physiological samples

Abstract

Keywords

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