TY - JOUR
T1 - Clinical features related to severity and mortality among COVID-19 patients in a pre-vaccine period in Luanda, Angola
AU - Sebastião, Cruz S.
AU - Cogle, Adis
AU - Teixeira, Alice D’Alva
AU - Cândido, Ana Micolo
AU - Tchoni, Chissengo
AU - Amorim, Maria João
AU - Loureiro, N’gueza
AU - Parimbelli, Paolo
AU - Penha-Gonçalves, Carlos
AU - Demengeot, Jocelyne
AU - Sacomboio, Euclides
AU - Mendes, Manuela
AU - Arrais, Margarete
AU - Morais, Joana
AU - Vasconcelos, Jocelyne Neto de
AU - Brito, Miguel
N1 - Publisher Copyright:
© 2022 by the authors.
PY - 2022/10/29
Y1 - 2022/10/29
N2 - Background: Infection due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with clinical features of diverse severity. Few studies investigated the severity and mortality predictors of coronavirus disease 2019 (COVID-19) in Africa. Herein, we investigated the clinical features of severity and mortality among COVID-19 patients in Luanda, Angola. Methods: This multicenter cohort study involved 101 COVID-19 patients, between December 2020 and April 2021, with clinical and laboratory data collected. Analysis was done using independent-sample t-tests and Chi-square tests. The results were deemed significant when p < 0.05. Results: The mean age of patients was 51 years (ranging from 18 to 80 years) and 60.4% were male. Fever (46%), cough (47%), gastrointestinal symptoms (26.7%), and asthenia (26.7%), were the most common symptoms. About 64.4% of the patients presented coexistent disorders, including hypertension (42%), diabetes (17%), and chronic renal diseases (6%). About 23% were non-severe, 77% were severe, and 10% died during hospitalization. Variations in the concentration of neutrophil, urea, creatinine, c-reactive protein, sodium, creatine kinase, and chloride were independently associated with severity and/or mortality (p < 0.05). Conclusion: Several factors contributed to the severity and mortality among COVID-19 patients in Angola. Further studies related to clinical features should be carried out to help clinical decision-making and follow-up of COVID-19 patients in Angola.
AB - Background: Infection due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with clinical features of diverse severity. Few studies investigated the severity and mortality predictors of coronavirus disease 2019 (COVID-19) in Africa. Herein, we investigated the clinical features of severity and mortality among COVID-19 patients in Luanda, Angola. Methods: This multicenter cohort study involved 101 COVID-19 patients, between December 2020 and April 2021, with clinical and laboratory data collected. Analysis was done using independent-sample t-tests and Chi-square tests. The results were deemed significant when p < 0.05. Results: The mean age of patients was 51 years (ranging from 18 to 80 years) and 60.4% were male. Fever (46%), cough (47%), gastrointestinal symptoms (26.7%), and asthenia (26.7%), were the most common symptoms. About 64.4% of the patients presented coexistent disorders, including hypertension (42%), diabetes (17%), and chronic renal diseases (6%). About 23% were non-severe, 77% were severe, and 10% died during hospitalization. Variations in the concentration of neutrophil, urea, creatinine, c-reactive protein, sodium, creatine kinase, and chloride were independently associated with severity and/or mortality (p < 0.05). Conclusion: Several factors contributed to the severity and mortality among COVID-19 patients in Angola. Further studies related to clinical features should be carried out to help clinical decision-making and follow-up of COVID-19 patients in Angola.
KW - Angola
KW - Clinical features
KW - COVID-19
KW - Luanda
KW - SARS-CoV-2
UR - http://www.scopus.com/inward/record.url?scp=85141748662&partnerID=8YFLogxK
U2 - 10.3390/tropicalmed7110338
DO - 10.3390/tropicalmed7110338
M3 - Article
C2 - 36355881
AN - SCOPUS:85141748662
SN - 2414-6366
VL - 7
JO - Tropical Medicine and Infectious Disease
JF - Tropical Medicine and Infectious Disease
IS - 11
M1 - 338
ER -
