Comparison of arterial spin labeling registration strategies in the multi-center GENetic frontotemporal dementia initiative (GENFI)

GENFI investigators; Henri J.M.M. Mutsaerts; Jan Petr; David L. Thomas; Enrico De Vita; David M. Cash; Matthias J.P. van Osch; Xavier Golay; Paul F.C. Groot; Sebastien Ourselin; John van Swieten; Robert Laforce; Fabrizio Tagliavini; Barbara Borroni; Daniela Galimberti; James B. Rowe; Caroline Graff; Francesca B. Pizzini; Elizabeth Finger; Sandro Sorbi; Miguel Castelo Branco; Jonathan D. Rohrer; Mario Masellis; Bradley J. MacIntosh; Martin Rossor; Nick Fox; Jason Warren; Martina Bocchetta; Katrina Dick; Michela Pievani; Roberta Ghidoni; Luisa Benussi; Alessandro Padovani; Maura Cosseddu; Alexandre Mendonça; Giovanni Frisoni; Enrico Premi; Silvana Archetti; Elio Scarpini; Giorgio Fumagalli; Andrea Arighi; Chiara Fenoglio; Sara Prioni; Veronica Redaelii; Marina Grisoli; Pietro Tiraboschi; Sandra Black; Ekaterina Rogaeva; Morris Freedman; Maria Carmela Tartaglia; Carolina Maruta

doi:10.1002/jmri.25751

Comparison of arterial spin labeling registration strategies in the multi-center GENetic frontotemporal dementia initiative (GENFI)

GENFI investigators, Henri J.M.M. Mutsaerts^*, Jan Petr, David L. Thomas, Enrico De Vita, David M. Cash, Matthias J.P. van Osch, Xavier Golay, Paul F.C. Groot, Sebastien Ourselin, John van Swieten, Robert Laforce, Fabrizio Tagliavini, Barbara Borroni, Daniela Galimberti, James B. Rowe, Caroline Graff, Francesca B. Pizzini, Elizabeth Finger, Sandro SorbiMiguel Castelo Branco, Jonathan D. Rohrer, Mario Masellis, Bradley J. MacIntosh, Martin Rossor, Nick Fox, Jason Warren, Martina Bocchetta, Katrina Dick, Michela Pievani, Roberta Ghidoni, Luisa Benussi, Alessandro Padovani, Maura Cosseddu, Alexandre Mendonça, Giovanni Frisoni, Enrico Premi, Silvana Archetti, Elio Scarpini, Giorgio Fumagalli, Andrea Arighi, Chiara Fenoglio, Sara Prioni, Veronica Redaelii, Marina Grisoli, Pietro Tiraboschi, Sandra Black, Ekaterina Rogaeva, Morris Freedman, Maria Carmela Tartaglia, Carolina Maruta

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Purpose: To compare registration strategies to align arterial spin labeling (ASL) with 3D T1-weighted (T1w) images, with the goal of reducing the between-subject variability of cerebral blood flow (CBF) images. Materials and Methods: Multi-center 3T ASL data were collected at eight sites with four different sequences in the multi-center GENetic Frontotemporal dementia Initiative (GENFI) study. In a total of 48 healthy controls, we compared the following image registration options: (I) which images to use for registration (perfusion-weighted images [PWI] to the segmented gray matter (GM) probability map (pGM) (CBF-pGM) or M0 to T1w (M0-T1w); (II) which transformation to use (rigid-body or non-rigid); and (III) whether to mask or not (no masking, M0-based FMRIB software library Brain Extraction Tool [BET] masking). In addition to visual comparison, we quantified image similarity using the Pearson correlation coefficient (CC), and used the Mann-Whitney U rank sum test. Results: CBF-pGM outperformed M0-T1w (CC improvement 47.2% ± 22.0%; P < 0.001), and the non-rigid transformation outperformed rigid-body (20.6% ± 5.3%; P < 0.001). Masking only improved the M0-T1w rigid-body registration (14.5% ± 15.5%; P = 0.007). Conclusion: The choice of image registration strategy impacts ASL group analyses. The non-rigid transformation is promising but requires validation. CBF-pGM rigid-body registration without masking can be used as a default strategy. In patients with expansive perfusion deficits, M0-T1w may outperform CBF-pGM in sequences with high effective spatial resolution. BET-masking only improves M0-T1w registration when the M0 image has sufficient contrast. Level of Evidence: 1. Technical Efficacy: Stage 1. J. Magn. Reson. Imaging 2018;47:131–140.

Original language	English
Pages (from-to)	131-140
Number of pages	10
Journal	Journal of Magnetic Resonance Imaging
Volume	47
Issue number	1
DOIs	https://doi.org/10.1002/jmri.25751
Publication status	Published - Jan 2018
Externally published	Yes

Keywords

Arterial spin labeling
Cerebral blood flow
Image registration

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10.1002/jmri.25751

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GENFI investigators, Mutsaerts, H. J. M. M., Petr, J., Thomas, D. L., De Vita, E., Cash, D. M., van Osch, M. J. P., Golay, X., Groot, P. F. C., Ourselin, S., van Swieten, J., Laforce, R., Tagliavini, F., Borroni, B., Galimberti, D., Rowe, J. B., Graff, C., Pizzini, F. B., Finger, E., ... Maruta, C. (2018). Comparison of arterial spin labeling registration strategies in the multi-center GENetic frontotemporal dementia initiative (GENFI). Journal of Magnetic Resonance Imaging, 47(1), 131-140. https://doi.org/10.1002/jmri.25751

GENFI investigators ; Mutsaerts, Henri J.M.M. ; Petr, Jan ; Thomas, David L. ; De Vita, Enrico ; Cash, David M. ; van Osch, Matthias J.P. ; Golay, Xavier ; Groot, Paul F.C. ; Ourselin, Sebastien ; van Swieten, John ; Laforce, Robert ; Tagliavini, Fabrizio ; Borroni, Barbara ; Galimberti, Daniela ; Rowe, James B. ; Graff, Caroline ; Pizzini, Francesca B. ; Finger, Elizabeth ; Sorbi, Sandro ; Castelo Branco, Miguel ; Rohrer, Jonathan D. ; Masellis, Mario ; MacIntosh, Bradley J. ; Rossor, Martin ; Fox, Nick ; Warren, Jason ; Bocchetta, Martina ; Dick, Katrina ; Pievani, Michela ; Ghidoni, Roberta ; Benussi, Luisa ; Padovani, Alessandro ; Cosseddu, Maura ; Mendonça, Alexandre ; Frisoni, Giovanni ; Premi, Enrico ; Archetti, Silvana ; Scarpini, Elio ; Fumagalli, Giorgio ; Arighi, Andrea ; Fenoglio, Chiara ; Prioni, Sara ; Redaelii, Veronica ; Grisoli, Marina ; Tiraboschi, Pietro ; Black, Sandra ; Rogaeva, Ekaterina ; Freedman, Morris ; Tartaglia, Maria Carmela ; Maruta, Carolina. / Comparison of arterial spin labeling registration strategies in the multi-center GENetic frontotemporal dementia initiative (GENFI). In: Journal of Magnetic Resonance Imaging. 2018 ; Vol. 47, No. 1. pp. 131-140.

@article{32de1654611f4f35885ffdbae7968114,

title = "Comparison of arterial spin labeling registration strategies in the multi-center GENetic frontotemporal dementia initiative (GENFI)",

abstract = "Purpose: To compare registration strategies to align arterial spin labeling (ASL) with 3D T1-weighted (T1w) images, with the goal of reducing the between-subject variability of cerebral blood flow (CBF) images. Materials and Methods: Multi-center 3T ASL data were collected at eight sites with four different sequences in the multi-center GENetic Frontotemporal dementia Initiative (GENFI) study. In a total of 48 healthy controls, we compared the following image registration options: (I) which images to use for registration (perfusion-weighted images [PWI] to the segmented gray matter (GM) probability map (pGM) (CBF-pGM) or M0 to T1w (M0-T1w); (II) which transformation to use (rigid-body or non-rigid); and (III) whether to mask or not (no masking, M0-based FMRIB software library Brain Extraction Tool [BET] masking). In addition to visual comparison, we quantified image similarity using the Pearson correlation coefficient (CC), and used the Mann-Whitney U rank sum test. Results: CBF-pGM outperformed M0-T1w (CC improvement 47.2% ± 22.0%; P < 0.001), and the non-rigid transformation outperformed rigid-body (20.6% ± 5.3%; P < 0.001). Masking only improved the M0-T1w rigid-body registration (14.5% ± 15.5%; P = 0.007). Conclusion: The choice of image registration strategy impacts ASL group analyses. The non-rigid transformation is promising but requires validation. CBF-pGM rigid-body registration without masking can be used as a default strategy. In patients with expansive perfusion deficits, M0-T1w may outperform CBF-pGM in sequences with high effective spatial resolution. BET-masking only improves M0-T1w registration when the M0 image has sufficient contrast. Level of Evidence: 1. Technical Efficacy: Stage 1. J. Magn. Reson. Imaging 2018;47:131–140.",

keywords = "Arterial spin labeling, Cerebral blood flow, Image registration",

author = "{GENFI investigators} and Mutsaerts, {Henri J.M.M.} and Jan Petr and Thomas, {David L.} and {De Vita}, Enrico and Cash, {David M.} and {van Osch}, {Matthias J.P.} and Xavier Golay and Groot, {Paul F.C.} and Sebastien Ourselin and {van Swieten}, John and Robert Laforce and Fabrizio Tagliavini and Barbara Borroni and Daniela Galimberti and Rowe, {James B.} and Caroline Graff and Pizzini, {Francesca B.} and Elizabeth Finger and Sandro Sorbi and {Castelo Branco}, Miguel and Rohrer, {Jonathan D.} and Mario Masellis and MacIntosh, {Bradley J.} and Martin Rossor and Nick Fox and Jason Warren and Martina Bocchetta and Katrina Dick and Michela Pievani and Roberta Ghidoni and Luisa Benussi and Alessandro Padovani and Maura Cosseddu and Alexandre Mendon{\c c}a and Giovanni Frisoni and Enrico Premi and Silvana Archetti and Elio Scarpini and Giorgio Fumagalli and Andrea Arighi and Chiara Fenoglio and Sara Prioni and Veronica Redaelii and Marina Grisoli and Pietro Tiraboschi and Sandra Black and Ekaterina Rogaeva and Morris Freedman and Tartaglia, {Maria Carmela} and Carolina Maruta",

year = "2018",

month = jan,

doi = "10.1002/jmri.25751",

language = "English",

volume = "47",

pages = "131--140",

journal = "Journal of Magnetic Resonance Imaging",

issn = "1053-1807",

publisher = "Wiley-Blackwell",

number = "1",

}

GENFI investigators, Mutsaerts, HJMM, Petr, J, Thomas, DL, De Vita, E, Cash, DM, van Osch, MJP, Golay, X, Groot, PFC, Ourselin, S, van Swieten, J, Laforce, R, Tagliavini, F, Borroni, B, Galimberti, D, Rowe, JB, Graff, C, Pizzini, FB, Finger, E, Sorbi, S, Castelo Branco, M, Rohrer, JD, Masellis, M, MacIntosh, BJ, Rossor, M, Fox, N, Warren, J, Bocchetta, M, Dick, K, Pievani, M, Ghidoni, R, Benussi, L, Padovani, A, Cosseddu, M, Mendonça, A, Frisoni, G, Premi, E, Archetti, S, Scarpini, E, Fumagalli, G, Arighi, A, Fenoglio, C, Prioni, S, Redaelii, V, Grisoli, M, Tiraboschi, P, Black, S, Rogaeva, E, Freedman, M, Tartaglia, MC & Maruta, C 2018, 'Comparison of arterial spin labeling registration strategies in the multi-center GENetic frontotemporal dementia initiative (GENFI)', Journal of Magnetic Resonance Imaging, vol. 47, no. 1, pp. 131-140. https://doi.org/10.1002/jmri.25751

Comparison of arterial spin labeling registration strategies in the multi-center GENetic frontotemporal dementia initiative (GENFI). / GENFI investigators; Mutsaerts, Henri J.M.M.; Petr, Jan; Thomas, David L.; De Vita, Enrico; Cash, David M.; van Osch, Matthias J.P.; Golay, Xavier; Groot, Paul F.C.; Ourselin, Sebastien; van Swieten, John; Laforce, Robert; Tagliavini, Fabrizio; Borroni, Barbara; Galimberti, Daniela; Rowe, James B.; Graff, Caroline; Pizzini, Francesca B.; Finger, Elizabeth; Sorbi, Sandro; Castelo Branco, Miguel; Rohrer, Jonathan D.; Masellis, Mario; MacIntosh, Bradley J.; Rossor, Martin; Fox, Nick; Warren, Jason; Bocchetta, Martina; Dick, Katrina; Pievani, Michela; Ghidoni, Roberta; Benussi, Luisa; Padovani, Alessandro; Cosseddu, Maura; Mendonça, Alexandre; Frisoni, Giovanni; Premi, Enrico; Archetti, Silvana; Scarpini, Elio; Fumagalli, Giorgio; Arighi, Andrea; Fenoglio, Chiara; Prioni, Sara; Redaelii, Veronica; Grisoli, Marina; Tiraboschi, Pietro; Black, Sandra; Rogaeva, Ekaterina; Freedman, Morris; Tartaglia, Maria Carmela; Maruta, Carolina.

In: Journal of Magnetic Resonance Imaging, Vol. 47, No. 1, 01.2018, p. 131-140.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Comparison of arterial spin labeling registration strategies in the multi-center GENetic frontotemporal dementia initiative (GENFI)

AU - GENFI investigators

AU - Mutsaerts, Henri J.M.M.

AU - Petr, Jan

AU - Thomas, David L.

AU - De Vita, Enrico

AU - Cash, David M.

AU - van Osch, Matthias J.P.

AU - Golay, Xavier

AU - Groot, Paul F.C.

AU - Ourselin, Sebastien

AU - van Swieten, John

AU - Laforce, Robert

AU - Tagliavini, Fabrizio

AU - Borroni, Barbara

AU - Galimberti, Daniela

AU - Rowe, James B.

AU - Graff, Caroline

AU - Pizzini, Francesca B.

AU - Finger, Elizabeth

AU - Sorbi, Sandro

AU - Castelo Branco, Miguel

AU - Rohrer, Jonathan D.

AU - Masellis, Mario

AU - MacIntosh, Bradley J.

AU - Rossor, Martin

AU - Fox, Nick

AU - Warren, Jason

AU - Bocchetta, Martina

AU - Dick, Katrina

AU - Pievani, Michela

AU - Ghidoni, Roberta

AU - Benussi, Luisa

AU - Padovani, Alessandro

AU - Cosseddu, Maura

AU - Mendonça, Alexandre

AU - Frisoni, Giovanni

AU - Premi, Enrico

AU - Archetti, Silvana

AU - Scarpini, Elio

AU - Fumagalli, Giorgio

AU - Arighi, Andrea

AU - Fenoglio, Chiara

AU - Prioni, Sara

AU - Redaelii, Veronica

AU - Grisoli, Marina

AU - Tiraboschi, Pietro

AU - Black, Sandra

AU - Rogaeva, Ekaterina

AU - Freedman, Morris

AU - Tartaglia, Maria Carmela

AU - Maruta, Carolina

PY - 2018/1

Y1 - 2018/1

N2 - Purpose: To compare registration strategies to align arterial spin labeling (ASL) with 3D T1-weighted (T1w) images, with the goal of reducing the between-subject variability of cerebral blood flow (CBF) images. Materials and Methods: Multi-center 3T ASL data were collected at eight sites with four different sequences in the multi-center GENetic Frontotemporal dementia Initiative (GENFI) study. In a total of 48 healthy controls, we compared the following image registration options: (I) which images to use for registration (perfusion-weighted images [PWI] to the segmented gray matter (GM) probability map (pGM) (CBF-pGM) or M0 to T1w (M0-T1w); (II) which transformation to use (rigid-body or non-rigid); and (III) whether to mask or not (no masking, M0-based FMRIB software library Brain Extraction Tool [BET] masking). In addition to visual comparison, we quantified image similarity using the Pearson correlation coefficient (CC), and used the Mann-Whitney U rank sum test. Results: CBF-pGM outperformed M0-T1w (CC improvement 47.2% ± 22.0%; P < 0.001), and the non-rigid transformation outperformed rigid-body (20.6% ± 5.3%; P < 0.001). Masking only improved the M0-T1w rigid-body registration (14.5% ± 15.5%; P = 0.007). Conclusion: The choice of image registration strategy impacts ASL group analyses. The non-rigid transformation is promising but requires validation. CBF-pGM rigid-body registration without masking can be used as a default strategy. In patients with expansive perfusion deficits, M0-T1w may outperform CBF-pGM in sequences with high effective spatial resolution. BET-masking only improves M0-T1w registration when the M0 image has sufficient contrast. Level of Evidence: 1. Technical Efficacy: Stage 1. J. Magn. Reson. Imaging 2018;47:131–140.

AB - Purpose: To compare registration strategies to align arterial spin labeling (ASL) with 3D T1-weighted (T1w) images, with the goal of reducing the between-subject variability of cerebral blood flow (CBF) images. Materials and Methods: Multi-center 3T ASL data were collected at eight sites with four different sequences in the multi-center GENetic Frontotemporal dementia Initiative (GENFI) study. In a total of 48 healthy controls, we compared the following image registration options: (I) which images to use for registration (perfusion-weighted images [PWI] to the segmented gray matter (GM) probability map (pGM) (CBF-pGM) or M0 to T1w (M0-T1w); (II) which transformation to use (rigid-body or non-rigid); and (III) whether to mask or not (no masking, M0-based FMRIB software library Brain Extraction Tool [BET] masking). In addition to visual comparison, we quantified image similarity using the Pearson correlation coefficient (CC), and used the Mann-Whitney U rank sum test. Results: CBF-pGM outperformed M0-T1w (CC improvement 47.2% ± 22.0%; P < 0.001), and the non-rigid transformation outperformed rigid-body (20.6% ± 5.3%; P < 0.001). Masking only improved the M0-T1w rigid-body registration (14.5% ± 15.5%; P = 0.007). Conclusion: The choice of image registration strategy impacts ASL group analyses. The non-rigid transformation is promising but requires validation. CBF-pGM rigid-body registration without masking can be used as a default strategy. In patients with expansive perfusion deficits, M0-T1w may outperform CBF-pGM in sequences with high effective spatial resolution. BET-masking only improves M0-T1w registration when the M0 image has sufficient contrast. Level of Evidence: 1. Technical Efficacy: Stage 1. J. Magn. Reson. Imaging 2018;47:131–140.

KW - Arterial spin labeling

KW - Cerebral blood flow

KW - Image registration

UR - http://www.scopus.com/inward/record.url?scp=85019064293&partnerID=8YFLogxK

U2 - 10.1002/jmri.25751

DO - 10.1002/jmri.25751

M3 - Article

C2 - 28480617

AN - SCOPUS:85019064293

VL - 47

SP - 131

EP - 140

JO - Journal of Magnetic Resonance Imaging

JF - Journal of Magnetic Resonance Imaging

SN - 1053-1807

IS - 1

ER -

Comparison of arterial spin labeling registration strategies in the multi-center GENetic frontotemporal dementia initiative (GENFI)

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Keywords

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