CRISPR-cas technology: emerging applications in clinical microbiology and infectious diseases

Sahar Serajian, Ehsan Ahmadpour, Sonia M. Rodrigues Oliveira, Maria de Lourdes Pereira, Siamak Heidarzadeh

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Through the years, many promising tools for gene editing have been developed including zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), CRISPR-associated protein 9 (Cas9), and homing endonucleases (HEs). These novel technologies are now leading new scientific advancements and practical applications at an inimitable speed. While most work has been performed in eukaryotes, CRISPR systems also enable tools to understand and engineer bacteria. The increase in the number of multi-drug resistant strains highlights a necessity for more innovative approaches to the diagnosis and treatment of infections. CRISPR has given scientists a glimmer of hope in this area that can provide a novel tool to fight against antimicrobial resistance. This system can provide useful information about the functions of genes and aid us to find potential targets for antimicrobials. This paper discusses the emerging use of CRISPR-Cas systems in the fields of clinical microbiology and infectious diseases with a particular emphasis on future prospects.
Original languageEnglish
Article number1171
Number of pages23
JournalPharmaceuticals
Volume14
Issue number11
DOIs
Publication statusPublished - Nov 2021
Externally publishedYes

Keywords

  • CRISPR
  • Gene editing
  • Infectious diseases
  • Antimicrobial resistance
  • Parasitology

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