Current evidence of tissue engineering for dentine regeneration in animal models: a systematic review

Gabriela S. da Silva, Maria Stella Moreira, Karen A. Fukushima, Daniela P. Raggio, Anna Carolina V Mello-Moura, Juan S. Lara, Thais Gimenez, Sergio Allegrini Junior, Susana Morimoto, Tamara K. Tedesco*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

16 Citations (Scopus)

Abstract

Aim: The aim of this study is to verify the type of scaffold effect on tissue engineering for dentine regeneration in animal models. Materials & methods: Strategic searches were conducted through MEDLINE/PubMed, Web of Science and Scopus databases. The studies were included with the following eligibility criteria: studies evaluating dentine regeneration, and being an in vivo study. Results: From 1392 identified potentially relevant studies, 15 fulfilled the eligibility criteria. All studies described characteristics of neoformed dentine, being that the most reported reparative dentine formation. Most of included studies presented moderate risk of bias. Conclusion: Up to date scientific evidence shows a positive trend to dentine regeneration when considering tissue engineering in animal models, regardless the type of scaffolds used.

Original languageEnglish
Pages (from-to)1345-1360
Number of pages16
JournalRegenerative Medicine
Volume15
Issue number2
DOIs
Publication statusPublished - Feb 2020
Externally publishedYes

Keywords

  • Dental caries
  • Dental pulp capping
  • Dentine
  • Stem cells
  • Systematic review
  • Tissue engineering
  • Tissue scaffolds
  • Tooth injuries

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