Current extraction techniques towards bioactive compounds from brewer’s spent grain: a review

T. Bonifácio-Lopes, José A. Teixeira, Manuela Pintado*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

46 Citations (Scopus)


Background: Brewer’s spent grain is one of the most abundant by-products of the brewing industry and is rich in various bioactive compounds (phenolic acids, insoluble dietary fiber and proteins). While at the present brewer’s spent grain is mainly used as animal feed its rich nutritional content makes it an interesting alternative for food applications. Scope and approach: As the range of applications of the bioactive compounds extracted from by-products has been growing in recent years, there is the need to obtain and characterize these bioactive compounds. Extraction methods (supercritical carbon dioxide, autohydrolysis, alkaline hydrolysis, solvent extraction, ultrasound assisted extraction, dilute acid hydrolysis, enzymatic hydrolysis, microwave assisted extraction) have been developed and are always being subjected to new approaches to allow better extraction yields of the bioactive compounds. Key findings and conclusions: This review aims to provide a better understanding of the current advantages and limitations of brewer’s spent grain extraction processes and to provide a background of brewer’s spent grain composition and applications. Highlights The re-use of agro-industrial by-products can origin new added-value products BSG is an agro-industrial by-product and is a source of various bioactive compounds Extraction methods have been applied to extract these compounds from BSG It is needed to find new techniques and new possible applications to the BSG.
Original languageEnglish
Pages (from-to)2730-2741
Number of pages12
JournalCritical Reviews in Food Science and Nutrition
Issue number16
Publication statusPublished - 2020


  • Bioactive compounds
  • Brewer’s spent grain
  • Chemical composition
  • Extraction techniques


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