Decreases in molecularity promote conversion when reactions are catalyzed by enzymes immobilized in slab-shaped beads

R. M. Barros, F. X. Malcata*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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Abstract

Application of Fick's first law to substrate undergoing chemical reaction catalyzed by an enzyme immobilized in a porous slab-shaped bead leads to substrate concentration profiles that are flatter when the ratio of stoichiometric coefficients of product to reactant (v) is lower. Since the actual effectiveness factor decreases when v increases (at approximately the same rate irrespective of the value taken by the Michaelis-Menten parameter), then considerable overprediction of the conversion levels obtained within a given reaction timeframe will occur if the simplistic (and more easily modelled) situation of equimolar counterdiffusion is taken for modelling purposes when v > 1.
Original languageEnglish
Pages (from-to)101-104
Number of pages4
JournalBioprocess Engineering
Volume20
Issue number2
DOIs
Publication statusPublished - 1999

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