Delayed auditory feedback simulates features of nonfluent primary progressive aphasia

Carolina Maruta, Sonya Makhmood, Laura E. Downey, Hannah L. Golden, Phillip D. Fletcher, Pirada Witoonpanich, Jonathan D. Rohrer, Jason D. Warren*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

The pathophysiology of nonfluent primary progressive aphasia (nfvPPA) remains poorly understood. Here, we compared quantitatively speech parameters in patients with nfvPPA versus healthy older individuals under altered auditory feedback, which has been shown to modulate normal speech output. Patients (n = 15) and healthy volunteers (n = 17) were recorded while reading aloud under delayed auditory feedback [DAF] with latency 0, 50 or 200 ms and under DAF at 200 ms plus 0.5 octave upward pitch shift. DAF in healthy older individuals was associated with reduced speech rate and emergence of speech sound errors, particularly at latency 200 ms. Up to a third of the healthy older group under DAF showed speech slowing and frequency of speech sound errors within the range of the nfvPPA cohort. Our findings suggest that (in addition to any anterior, primary language output disorder) these key features of nfvPPA may reflect distorted speech input signal processing, as simulated by DAF. DAF may constitute a novel candidate pathophysiological model of posterior dorsal cortical language pathway dysfunction in nfvPPA.
Original languageEnglish
Pages (from-to)345-348
Number of pages4
JournalJournal of the Neurological Sciences
Volume347
Issue number1-2
DOIs
Publication statusPublished - 15 Dec 2014
Externally publishedYes

Keywords

  • Altered auditory feedback
  • Delayed auditory feedback
  • Dementia
  • Dorsal pathway
  • Language
  • Progressive aphasia

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