TY - JOUR
T1 - Delayed auditory feedback simulates features of nonfluent primary progressive aphasia
AU - Maruta, Carolina
AU - Makhmood, Sonya
AU - Downey, Laura E.
AU - Golden, Hannah L.
AU - Fletcher, Phillip D.
AU - Witoonpanich, Pirada
AU - Rohrer, Jonathan D.
AU - Warren, Jason D.
N1 - Funding Information:
The authors thank the patients and healthy volunteers for their participation. This work was undertaken at UCLH/UCL, who received a proportion of funding from the Department of Health's NIHR Biomedical Research Centres funding scheme (Grant CBRC 161 ). The Dementia Research Centre is an Alzheimer Research UK Co-ordinating Centre. CM is supported by a Fundação para a Ciência e Tecnologia PhD Fellowship (ref.: SFRH/BD/75710/2011 ). HLG is supported by an Alzheimer Research UK PhD Fellowship (Grant ART-PhD2011-10 ). PDF is supported by an MRC Research Training Fellowship (Grant MR/J011274/1 ). JDW is supported by a Wellcome Trust Senior Clinical Fellowship (Grant No 091673/Z/10/Z ).
Publisher Copyright:
© 2014 The Authors.
PY - 2014/12/15
Y1 - 2014/12/15
N2 - The pathophysiology of nonfluent primary progressive aphasia (nfvPPA) remains poorly understood. Here, we compared quantitatively speech parameters in patients with nfvPPA versus healthy older individuals under altered auditory feedback, which has been shown to modulate normal speech output. Patients (n = 15) and healthy volunteers (n = 17) were recorded while reading aloud under delayed auditory feedback [DAF] with latency 0, 50 or 200 ms and under DAF at 200 ms plus 0.5 octave upward pitch shift. DAF in healthy older individuals was associated with reduced speech rate and emergence of speech sound errors, particularly at latency 200 ms. Up to a third of the healthy older group under DAF showed speech slowing and frequency of speech sound errors within the range of the nfvPPA cohort. Our findings suggest that (in addition to any anterior, primary language output disorder) these key features of nfvPPA may reflect distorted speech input signal processing, as simulated by DAF. DAF may constitute a novel candidate pathophysiological model of posterior dorsal cortical language pathway dysfunction in nfvPPA.
AB - The pathophysiology of nonfluent primary progressive aphasia (nfvPPA) remains poorly understood. Here, we compared quantitatively speech parameters in patients with nfvPPA versus healthy older individuals under altered auditory feedback, which has been shown to modulate normal speech output. Patients (n = 15) and healthy volunteers (n = 17) were recorded while reading aloud under delayed auditory feedback [DAF] with latency 0, 50 or 200 ms and under DAF at 200 ms plus 0.5 octave upward pitch shift. DAF in healthy older individuals was associated with reduced speech rate and emergence of speech sound errors, particularly at latency 200 ms. Up to a third of the healthy older group under DAF showed speech slowing and frequency of speech sound errors within the range of the nfvPPA cohort. Our findings suggest that (in addition to any anterior, primary language output disorder) these key features of nfvPPA may reflect distorted speech input signal processing, as simulated by DAF. DAF may constitute a novel candidate pathophysiological model of posterior dorsal cortical language pathway dysfunction in nfvPPA.
KW - Altered auditory feedback
KW - Delayed auditory feedback
KW - Dementia
KW - Dorsal pathway
KW - Language
KW - Progressive aphasia
UR - http://www.scopus.com/inward/record.url?scp=84920138695&partnerID=8YFLogxK
U2 - 10.1016/j.jns.2014.09.039
DO - 10.1016/j.jns.2014.09.039
M3 - Article
C2 - 25305712
AN - SCOPUS:84920138695
SN - 0022-510X
VL - 347
SP - 345
EP - 348
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
IS - 1-2
ER -