Desenvolvimento, produção e caracterização de nanocristais de fármacos pouco solúveis

Translated title of the contribution: Development, production and characterization of nanocrystals of poorly soluble drugs

Joana F. Fangueiro*, Inês R. Marques, Patrícia Severino, Maria Helena A. Santana, Eliana B. Souto

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Poorly soluble drugs have low bioavailability, representing a major challenge for the pharmaceutical industry. Processing drugs into the nanosized range changes their physical properties, and these are being used in pharmaceutics to develop innovative formulations known as Nanocrystals. Use of nanocrystals to overcome the problem of low bioavailability, and their production using different techniques such as microfluidization or high pressure homogenization, was reviewed in this paper. Examples of drugs, cosmetics and nutraceutical ingredients were also discussed. These technologies are well established in the pharmaceutical industry and are approved by the Food and Drug Administration.

Translated title of the contributionDevelopment, production and characterization of nanocrystals of poorly soluble drugs
Original languagePortuguese
Pages (from-to)1848-1853
Number of pages6
JournalQuimica Nova
Volume35
Issue number9
DOIs
Publication statusPublished - 2012
Externally publishedYes

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